by Dr. Trupti Shirole on  December 11, 2015 at 11:19 PM Research News
 Researchers Provide New Insights into Link Between Taste and Behavior
The brainstem circuits act as our life support system. They mediate vital taste related behaviors. But, the principles of gustatory computations in these circuits are poorly understood. Researchers at NERF (VIB/KU Leuven/imec) studied how the evolutionary conserved brainstem circuits of zebrafish encode gustatory information.

The team showed that taste categories are represented by dissimilar brainstem responses and generate different behaviors. They also showed that the concentration of sour and bitter tastes are encoded by different principles and with different levels of sensitivity.

Nuria Vendrell Llopis (NERF) said, "Our results suggest that these interactions in early brainstem circuits can result in non-linear computations, such as dynamic gain modulation and discrete representation of taste mixtures, which can be utilized for detecting food items at broad range of concentrations of tastes and rejecting inedible substances."

Emre Yaksi (NERF) said, "This is the first study focusing on the gustatory computations in brainstem circuits, at such an exhaustive level, combining functional brain imaging, applied mathematics and animal behavior. Our results propose a central role for encoding category, concentration and mixtures of taste in evolutionary conserved brainstem circuits of vertebrates. These kind of computations were up to now thought to be unique to higher centers at the level of gustatory cortex, mainly due to the difficulty of studying these questions in mammalian brainstem that is hard to access for in vivo physiology. At NERF we have the tools to do so leading to these new insights."

Source: Eurekalert

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