Research Implicates ClC-3 Chloride Channel in Hippocampal Neuronal Cell Death

Previous research has explained how over-production of nitric oxide and ion disturbance result in neuronal cell death around the ischemic area following ischemic brain injury.

Prof. Quanzhong Chang and team from Zhuhai Campus of Zunyi Medical College in China established a rat model of hippocampal neuronal apoptosis by using 3-morpholinosyndnomine (SIN-1), a nitric oxide donor. The models were then administered the chloride channel blocker, 4,4'-diisothiocyanostilbene-2,2'-disulfonic acid (DIDS), in a broader attempt to observe ClC-3 chloride channel expression in the neuronal apoptosis process and to investigate the correlation between chloride channel activity and ischemia-sensitive neuronal apoptosis. Their results showed that SIN-1 reduced the neuronal survival rate, induced neuronal apoptosis, and promoted ClC-3 chloride channel protein and mRNA expression in the apoptotic neurons. DIDS reversed the effect of SIN-1. These findings, published in the Neural Regeneration Research (Vol. 8, No. 32, 2013), indicate that the increased activities of the ClC-3 chloride channel may be involved in hippocampal neuronal apoptosis induced by nitric oxide.

Stroke – Early Warning Signs - Risk Factor - Rehab - Treatment
Stroke can cause permanent disability and it is important to recognize its early warning signs to stop its progress. Early warning signs of stroke include sudden weakness of facial muscles.

Source-Eurekalert

How to Deal with a Stroke - Signs - Symptoms - Risk Factors - Prevention
Stroke is a brain attack, which occurs when the blood supply to the brain is interrupted. It affects all age groups; according to the WHO, 15 million people are affected by stroke annually.

Stress and the Gender Divide-Mars and Venus-Biology-Different Strokes
Stress has become entwined in the current lifestyle of a young working couple and has resulted in the rise in incidence of hypertension, diabetes and psychosomatic illnesses.