About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Rat Studies Show Very Low Dose Aspirin Reduces Bleeding in Portal Hypertension

by Medindia Content Team on October 10, 2007 at 7:02 PM
Font : A-A+

Rat Studies Show Very Low Dose Aspirin Reduces Bleeding in Portal Hypertension

Studies on rats with portal hypertension have indicated that an ultra low-dose aspirin has a normalizing effect of platelet-endothelial cell alterations and bleeding time, mediated by Cyclooxygenase 2 inhibition.

This study, performed by a team led by Professor C. Doutremepuich, is described in a research article to be published in the October 14 issue of the World Journal of Gastroenterology.

Advertisement

Portal hypertension is a major complication of chronic liver disease, and bleeding is one of its most severe problems, leading often to death. Currently no treatment is used to modify the altered platelet activity observed in this pathology.

Ultra-low-dose aspirin has a prothrombotic effect that is the opposite of that observed with usual doses for the prevention of stroke or heart attack. The antithrombotic properties of low-dose aspirin are achieved by the inhibition of COX 1 in platelets. Aspirin is the most widely used antithrombotic agent. Previous research in rats has shown that the prothrombotic properties of ultra-low-dose aspirin are not mediated by platelets but by endothelial cells, and as such they have the potential of reversing the platelet-endothelial cell interaction alterations observed in portal hypertension.
Advertisement

In the view of the authors, to date no clear explanation has existed to elucidate the effect of such a small dose of aspirin, and no mechanism has been found to explain this contradictory action.

The prothrombotic effects of COX 2 inhibitors became evident in 2004 when one of the most widely accepted non-steroidal anti-inflammatory drugs was withdrawn from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use. Only aspirin has been demonstrated to have a prothrombotic effect at a very low dose.

In an elegant study design, including a model of in vivo Laser induced thrombosis in rats, bleeding time and prostanoid dosing, this research was performed by doctors from the Laboratory of Haematology of the Faculty of Pharmacy at the University of Bordeaux 2, France, Laboratoires Boiron and from the CEBBAD, Universidad Maimonides, Buenos Aires, Argentina.

Further research should explain the consequences of COX 2 inhibition produced by ultra-low doses of aspirin.

Source: Eurekalert
GAN /J
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
Turmeric: Magic Ingredient to Keep you Healthy in Winter
Top 7 Benefits of Good Oral Hygiene
Healthy and Safer Thanksgiving 2021
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Diet Lifestyle and Heart Disease Diet and High Blood Pressure Chemotherapy Chemotherapy Drugs Stress and the Gender Divide Silent Killer Diseases Quiz on Hypertension Anticoagulants Healthy Living von Willebrand Disease 

Recommended Reading
Priority For Beta Blockers Against Variceal Bleeding
Scientists opine that beta blockers should be the first line of prevention against variceal ......
Anticoagulants
Anticoagulants prevent the clotting of blood in our body. They are administered orally or via ......
Chemotherapy
‘Chemo’ means medicine or ‘drug’; ‘therapy’ means ‘treatment’. Chemotherapy refers to the use of cy...
Chemotherapy Drugs
Chemotherapy drugs perform like ‘magic bullets’ to destroy cancer cells in the body....
Diet and High Blood Pressure
High blood pressure or hypertension is defined as a blood pressure of above 140 mm Hg (systolic) and...
Stress and the Gender Divide
Stress has become entwined in the current lifestyle of a young working couple and has resulted in th...
von Willebrand Disease
von Willebrand's Disease (vWD) is an autosomal dominant inherited bleeding disorder that occurs from...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use