Cognitive decline even in people who carry APOE4 gene, which is a common risk factor of Alzheimer's disease can be prevented with enhanced lifestyle counselling.
The two-year FINGER trial involved 60-77 year-old people living in Finland and with risk factors for memory disorders. The new study was published in JAMA Neurology.
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‘Development of enhanced counselling methods like nutrition counselling, physical and cognitive exercises can help prevent dementia.’
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The study participants were divided into two groups: one of the groups was given regular lifestyle counselling and the other enhanced lifestyle counselling.
Enhanced counselling involved nutrition counselling, physical and cognitive exercises, and support in managing the risk of cardiovascular diseases.
![Severity of Delirium After Surgery Linked to Cognitive Decline]( "Severity of Delirium After Surgery Linked to Cognitive Decline")
Cognitive decline after surgery increases in patients with severe delirium and decline in cognition could be substantial and long-term.
Earlier findings from the FINGER trial have shown that the regular lifestyle counselling group had a significantly increased risk of cognitive and functional impairment compared to the intervention group, i.e. the group receiving enhanced counselling.
Now the researchers analysed whether the presence of the APOE4 gene affected the intervention results.
The analysis included 1,109 persons of whom 362 were carriers of the APOE4 gene. The findings show that enhanced lifestyle counselling prevented cognitive decline despite the presence of the risk gene. Analyses carried out within the groups also indicate that the intervention results might even be better in carriers of the APOE4 gene.
"Many people worry that genetic risk factors for dementia may thwart potential benefits from healthy lifestyle changes. We were very happy to see that this was not the case in our intervention, which was started early, before the onset of substantial cognitive impairment," says Adjunct Professor Alina Solomon, the lead author of the study.
Professor Miia Kivipelto, the principal investigator of the FINGER trial, adds: "The FINGER intervention model is now being adapted and tested globally in the World Wide FINGERS initiative. New clinical trials in diverse populations with a variety of geographical and cultural backgrounds will help us formulate global dementia prevention strategies".
Source: Eurekalert
Severity of Delirium After Surgery Linked to Cognitive Decline
Cognitive decline after surgery increases in patients with severe delirium and decline in cognition could be substantial and long-term.
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Earlier findings from the FINGER trial have shown that the regular lifestyle counselling group had a significantly increased risk of cognitive and functional impairment compared to the intervention group, i.e. the group receiving enhanced counselling.
Now the researchers analysed whether the presence of the APOE4 gene affected the intervention results.
The analysis included 1,109 persons of whom 362 were carriers of the APOE4 gene. The findings show that enhanced lifestyle counselling prevented cognitive decline despite the presence of the risk gene. Analyses carried out within the groups also indicate that the intervention results might even be better in carriers of the APOE4 gene.
"Many people worry that genetic risk factors for dementia may thwart potential benefits from healthy lifestyle changes. We were very happy to see that this was not the case in our intervention, which was started early, before the onset of substantial cognitive impairment," says Adjunct Professor Alina Solomon, the lead author of the study.
Professor Miia Kivipelto, the principal investigator of the FINGER trial, adds: "The FINGER intervention model is now being adapted and tested globally in the World Wide FINGERS initiative. New clinical trials in diverse populations with a variety of geographical and cultural backgrounds will help us formulate global dementia prevention strategies".
Source: Eurekalert
Age-related Hearing Loss Increases Risk of Cognitive Decline, Dementia
Age-related hearing loss has become very common and was found to be associated to increasing the risk of cognitive decline, impairment and dementia.
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 Resorting to MIND Diet may Slow Cognitive Decline in Stroke SurvivorsMIND diet which includes regular consumption of green vegetables, berries, fish and olive oil promotes brain health and helps slow cognitive decline in stroke survivors. | Advertisement
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