About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Prediction of Impending Preterm Birth may be Helped by Novel Blood Test

by Dr. Enozia Vakil on May 15, 2014 at 6:15 PM
Font : A-A+

 Prediction of Impending Preterm Birth may be Helped by Novel Blood Test

Predictions whether 70% of female study participants with threatened preterm labor (TPIL) would or would not give birth prematurely has been done with a blood based diagnostic test. Results were published May 14, 2014, in the open access journal PLOS ONE, by Dr Jan Heng and Professor Stephen Lye from the Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Canada. "A lot of TPTL women are unnecessarily hospitalized," says Professor Stephen Lye.

"We want to develop a test that can differentiate between true and false labor so that women in true labor can receive the appropriate medical care while women in false labor will receive supportive care and be discharged." Preterm birth worldwide remains the main cause of childbirth-related mortality in the developed world. Only 5% of the women hospitalized with signs of premature labor (i.e. TPTL) will deliver a premature baby within ten days. The current preterm labor diagnostic test, fetal fibronectin (fFN) test is easily influenced by factors that can cause false positives.

Advertisement

Thus, many women are ineligible for fFN testing. In an effort to develop a method that can be used in all cases, scientists used microarrays to study differential whole blood gene expression associated with spontaneous premature birth within 48 hours in women admitted with TPTL - an important window for the clinical management of TPTL. Blood samples were collected prior to treatment from ~150 TPTL women.

The fFN test was also performed on eligible participants (~60 women), and the results were compared. The researchers discovered that a set of nine genes, coupled with clinical blood data, could classify whether 70% of participants would or would not have a spontaneous preterm birth within 48 hours of hospital admission. In addition, the nine genes coupled with clinical blood data outperformed the fFN test. This newer test highlights the advantages of utilizing a blood-based diagnostic test to predict spontaneous preterm birth, where it can be performed on all women and as part of routine blood work.



Source: Eurekalert
Advertisement
Advertisement
Advertisement

Recommended Reading

This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Prediction of Impending Preterm Birth may be Helped by Novel Blood Test Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests