About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Potential Protein Targets for Malaria Vaccine Identified

by VR Sreeraman on November 1, 2008 at 12:40 PM
 Potential Protein Targets for Malaria Vaccine Identified

Researchers from Nijmegen and Leiden have found potential malarial therapeutic targets that may in the development of a vaccine to treat the disease.

They have identified a large number of parasite proteins that help in bringing human malaria vaccine closer to reality.

Advertisement

Malaria is spread by mosquito bite, once injected the parasites migrate to the liver where they mature and then their sporozoites (infective cells) are released into the blood, causing disease and fatal complications.

During the study the researchers genetically modified the proteins essential for sporozoite development, and could weaken these parasites such that they invade liver cells and stimulate an immune response, but don't develop further.
Advertisement

Previous studies have shown how to successfully vaccinate mice using a rodent malaria which had one of these liver stage genes removed, specifically p36p.

The researchers showed the first transition of such a vaccination from the rodent system to humans, by inactivating the equivalent gene (p52) in the major human malaria parasite, P. falciparum. These human parasites are unable to develop in liver cells.

The researchers believe that the findings may open up new pathways for its use as a human vaccine.

The findings are published October 31st in the open-access journal PLoS Pathogens.

Source: ANI
SRM
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Insight into Cellular Stress: Mechanisms Behind mRNA Sequestration Revealed
The discovery deepens our understanding of m6A biology and stress granule formation, with implications for neurodegenerative diseases.
Disrupted Circadian Rhythm Elevates the Risk of Parkinson's Disease
Trouble with sleep and the body's clock may increase your risk for Parkinson's, as per a new study.
A Wake-Up Call for Women — Hot Flashes Could Point to Alzheimer's Risk
New study uncovers a link between nocturnal hot flashes and Alzheimer's risk in menopausal women, suggesting a potential biomarker.
Breakthrough Brain-Centered Approach Reduces Chronic Back Pain
Our discovery revealed that a minority of individuals attributed their chronic pain to their brain's involvement.
New Statement to Protect Athletes' Health Published
Relative Energy Deficiency in Sport syndrome is overlooked by athletes and can be worsened by 'sports culture' due to its perceived short-term performance benefits.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
MediBotMediBot
Greetings! How can I assist you?MediBot
×

Potential Protein Targets for Malaria Vaccine Identified Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests