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Pancreatic Cancer Study Discovers New Genetic Risk Markers

by Vishnuprasad on August 5, 2014 at 6:48 PM
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 Pancreatic Cancer Study Discovers New Genetic Risk Markers

A new discovery has been made with the help of large DNA analysis of humans, which says that there are several genetic markers to spot pancreatic cancer.

The scientists from Dana-Farber Cancer Institute said that the markers were variations in the inherited DNA code at particular locations along chromosomes, and many of them signaled the increased risk of developing the highly lethal disease.


They analyzed DNA from 7,683 patients with pancreatic cancer and 14,397 control patients without this cancer, all of European descent, from the US, Europe, Canada, and Australia.

Brian Wolpin, MD, MPH, first author of the report, said that the results confirmed the presence of four risk associated SNPs that had been identified in a previous, smaller genome-wide association study (GWAS).

In addition, five new risk markers were discovered and a sixth that was of borderline statistical significance. The risks associated to each SNP or marker were largely independent and additive, so that they may have utility in future attempts to identify individuals in the general population at higher risk for pancreatic cancer.

The average lifetime risk of pancreatic cancer is 1.5%. Pancreatic cancer is a cancer that occurs in the cells lining the ducts or the islet cells of the pancreas, a digestive organ that sits in the upper abdomen surrounded by the stomach, small intestine, liver, spleen and gall bladder.

The study is published online by Nature Genetics

Source: Medindia


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