Overeating cuts the brain's natural brakes on food intake. This, in turn, would result in neurological changes that continue to fuel unhealthy eating and would lead to obesity, reveals a study in mice.
The results demonstrate how diet-induced obesity alters the function of a crucial neurological feeding suppression system - findings that could help identify novel therapeutic targets for eating disorders and obesity in humans.
Obesity, a disease that affects more than 500 million adults worldwide and is a large factor in the increased incidence of a myriad of other serious health issues, is often considered to be one of the most pressing global health concerns. While obesity can be linked to a few, rarely occurring medical causes, unhealthy eating habits are widely recognized as the largest determinant. However, little is known about how obesity impacts the brain or underlying neurological mechanisms, to contribute to these adverse eating behaviors.