New review brings together major milestones in the development of systems approaches to the modeling and study of Parkinson's disease and Deep Brain Stimulation (DBS). The study is published in WIREs Systems Biology and Medicine.
Systems biologists, physicists, and engineers have intensively worked at computational tools to analyze, predict, and optimize the effects of DBS to treat chronic neurological diseases. These efforts often have overlapping objectives and closely-related methods, but they are rarely compared, combined, or jointly discussed, perhaps because they often target different research communities.
The review takes into account the approaches that acknowledge the interactive nature and interdependence of various factors to optimize the therapeutic effects of DBS in individual patients.