New Strategy Helps Reverse Autism Behavioral Abnormalities

by Colleen Fleiss on  October 22, 2019 at 12:55 AM Child Health News
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A new and easy therapeutic strategy that may help reverse autism behavioral abnormalities has been discovered by Baylor College of Medicine scientists.
New Strategy Helps Reverse Autism Behavioral Abnormalities
New Strategy Helps Reverse Autism Behavioral Abnormalities

Autism is a developmental disorder that affects 1 in 59 children in the U.S. Mutations in specific genes, such as PTEN, can explain many autism cases. While children with mutations in PTEN exhibit autism, macrocephaly (an abnormally large skull), intellectual disability and epilepsy, there are currently no effective treatment options for children affected by this condition.

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Published today in Nature Medicine, the study showed that a previously unexplored pathway goes awry in the brain of PTEN-deficient mice, and its restoration reverses their behavioral and neurophysiological abnormalities. "PTEN is associated with the mTOR signaling pathway, which includes two distinct molecular complexes -- mTORC1 and mTORC2 -- each one regulating different cellular functions," said first author Chien-Ju Chen, a graduate student in the lab of corresponding author Dr. Mauro Costa-Mattioli, professor of neuroscience and Cullen Foundation Endowed Chair at Baylor College of Medicine.

Based largely on experiments with the drug rapamycin, it was widely believed that dysregulation of mTORC1 is responsible for the condition. However, Costa-Mattioli and his colleagues suspected that this was not the entire story since mTORC2 activity was also dysregulated in individuals with mutations in PTEN.

The researchers worked with a model of this condition in which mice were genetically engineered to lack PTEN specifically in neurons, the nerve cells of the brain. PTEN-deficient mice present with macrocephaly, seizures, shorter lifespan, alterations in social behaviors as well as memory problems similar to those observed in patients with autism spectrum disorders.

The investigators used molecular genetics techniques to independently suppress mTORC1 and mTORC2 and determined how individual silencing of these complexes affected the neurological alterations. "The results were quite surprising because they went against the traditional view of the field," said Costa-Mattioli, who also is director of the Memory and Brain Research Center at Baylor College of Medicine.

"It did not affect survival, the behavioral alterations or even the number seizures. Unexpectedly, genetically silencing mTORC2 complex activity resulted in prolonged lifespan, suppressed seizures, rescue of long-term memory and reduced autism spectrum disorder-like behaviors," Costa-Mattioli said.

Currently, there is no drug that could specifically inhibit mTORC2. Thinking of possible future clinical applications of these findings, the researchers developed an antisense oligonucleotide, a molecule that silences the activity of mTORC2 by preventing the synthesis of one of its defining components.

"Amazingly, when we administered a single injection of the anti-sense oligonucleotide, we were able to reverse the abnormal behaviors and reduce seizures in Pten-deficient mice," Chen said.

These findings are important because research efforts have mainly been focused on developing drugs to modulate mTORC1. Costa-Mattioli and his colleagues found that brain size and behavior are regulated by different mTOR complexes and molecular processes. More importantly, they found that mTORC2 is the major driver of the behavioral and other neurological alterations in PTEN-deficient mice, and their findings suggest that modulation of mTORC2 activity is a promising therapeutic approach.

"For other conditions, like spinal muscular atrophy, anti-sense oligonucleotides have successfully been translated into the clinic. This opens the possibility that either this or drug-based therapeutic modulation of mTORC2 activity also could be developed into a promising strategy to treat neurological disorders in which mTORC2 activity is dysregualted," Costa-Mattioli said.

Finally, mTOR signaling also is altered in other neurological disorders, including epilepsy, tuberous sclerosis, Fragile X syndrome and Alzheimer disease. Future experiments should determine whether mTORC2 also is the main mTOR complex implicated in these disorders.

Source: Eurekalert

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