Medindia
Advertisement

New Routes to Treating Osteoarthritis

by Colleen Fleiss on January 22, 2019 at 3:16 AM
Font : A-A+

New Routes to Treating Osteoarthritis

Scientists have discovered new genes and biological pathways linked to osteoarthritis, which could help identify starting points for new medicines.

In the largest genetic study of osteoarthritis to date, scientists have uncovered 52 new genetic changes linked to the disease, which doubles the number of genetic regions associated with the disabling condition.

Advertisement


Scientists at the Wellcome Sanger Institute, GSK and their collaborators analysed the genomes of over 77,000 people with osteoarthritis. Their findings, published today in Nature Genetics, highlighted opportunities for existing medicines to be evaluated in osteoarthritis.

There is no disease-modifying treatment for osteoarthritis. The disease is managed with pain relief medications and often culminates in joint replacement surgery, which has variable outcomes. Osteoarthritis is the most prevalent musculoskeletal disease and a leading cause of disability worldwide. In the UK, the disease indirectly costs the economy £14.8 billion each year*.
Advertisement

To uncover the genetics underpinning osteoarthritis, scientists from the Sanger Institute, GSK and their collaborators analysed the whole genomes of over 77,000 people with osteoarthritis and over 370,000 healthy people using patient data from the UK Biobank resource and the arcOGEN study**. The team studied many different types of osteoarthritis, including in knee and hip joints.

Professor Eleftheria Zeggini, previously from the Wellcome Sanger Institute and now based at Helmholtz Zentrum München in Germany, said: "Osteoarthritis is a very common, disabling disease with no cure. We have conducted the largest study of osteoarthritis to date, and found over 50 new genetic changes that increase the risk of developing osteoarthritis. This is a major step forward in developing treatments to help the millions of people suffering from the disease."

In order to discover which genes cause osteoarthritis, the team incorporated additional functional genomic data and analysed gene activity by measuring gene expression down to the protein level. The team integrated genetic and proteomic data on tissue taken from patients undergoing joint replacement surgery. By incorporating many different data sets, scientists were able to identify which genes were likely to be causal for osteoarthritis.

Ten of the genes were highlighted as targets of existing drugs, which are either in clinical development or approved for use against osteoarthritis and other diseases. These include the drugs INVOSSA, which is registered for knee osteoarthritis, and LCL-161, a drug in clinical development for the treatment of breast cancer, leukaemia and myeloma. The team suggest that the ten drugs highlighted would be good candidates for testing in osteoarthritis.

Dr Stephen Simpson, Director of Research at Versus Arthritis, who supported the arcOGEN study, said: "Osteoarthritis affects over 8.5 million people across the UK. We know that the condition impacts people in different ways, meaning the treatment that works for one person doesn't always work for someone else.

"This study represents a hugely important milestone towards understanding the complexity of osteoarthritis and finding new treatments and we are delighted that our support for the arcOGEN study has helped deliver this. In the long term, the research progresses us significantly on the journey to ending the pain, isolation and fatigue of those living with arthritis."

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Gonorrhea
World Alzheimer's Day 2021 - 'Know Dementia, Know Alzheimer's
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Osteoarthritis Hypermobility Syndrome Back Pain at Workplace: Prevention and Exercises Knee Replacement Surgery Diet, Nutrition and Supplements for Osteo-Arthritis and Rheumatoid Arthritis Hip Replacement Surgery Avascular Necrosis Psoriatic Arthritis Stickler Syndrome 

Recommended Reading
Osteoarthritis
Osteoarthritis is one of the commonest joint disorder and occurs as we age due to wear and tear of ....
Quiz on Arthritis
Do you know that there are more than 100 types of arthritis? If you think that only old people ......
Hormone Therapy may be Protective Against Knee Joint Osteoarthritis
Women who received hormone therapy (HT) had a lower prevalence of knee joint osteoarthritis, finds ....
Knee Joint Injuries May Lead to Osteoarthritis
Knee joint injuries are often related to sports, such as football, rugby or ice hockey may lead to ....
Avascular Necrosis
Avascular necrosis or Osteonecrosis affects the bone and occurs because of the interruption to its b...
Back Pain at Workplace: Prevention and Exercises
Understanding the basics about our back and our posture is very important in preventing back pain an...
Diet, Nutrition and Supplements for Osteo-Arthritis and Rheumatoid Arthritis
Rheumatoid arthritis patients should consume a diet rich in natural antioxidant and anti-inflammator...
Hip Replacement Surgery
Hip joint replacement has been instrumental in transforming the lives of many who had been disabled ...
Hypermobility Syndrome
Hypermobility Syndrome is a condition in which a person can move his joints far beyond the normal .....
Psoriatic Arthritis
Psoriatic arthritis is a kind of autoimmune inflammatory arthritis, which develops in 30 percent of ...
Stickler Syndrome
Stickler Syndrome is a rare genetic disorder which causes multisystem disorders predominantly affect...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use