Newly developed nanocomposite biomaterial heart-valve can reduce or eliminate complications related to heart transplants, according to a new study led by a team of researchers at UBC.
By using a newly developed technique, the researchers were able to build a more durable valve that enables the heart to adapt faster and more seamlessly.
Prosthetic Heart Valves
A prosthetic heart valve is an artificial device surgically implanted into the heart to replace a heart valve that has become damaged.
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‘New heart valve developed using naturally derived nanocomposites can reduce or eliminate complications related to heart transplants, thereby offering fresh hope for high-risk patients.’
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Assistant Professor Hadi Mohammadi runs the Heart Valve Performance Laboratory (HVPL) through UBC Okanagan's School of Engineering. Lead author on the study, he says the newly developed valve is an example of a transcatheter heart valve, a promising new branch of cardiology. These valves are unique because they can be inserted into a patient through small incisions rather than opening a patient's chest--a procedure that is generally safer and much less invasive.
"Existing transcatheter heart valves are made of animal tissues, most often the pericardium membrane from a cow's heart, and have had only moderate success to date," explains Mohammadi. "The problem is that they face significant implantation risks and can lead to coronary obstruction and acute kidney injury."
![New Type of Immune Cells for Forming Heart Valves]( "New Type of Immune Cells for Forming Heart Valves")
New light on critical role of heart-derived macrophages has been shed by a research team from UCLA. Macrophages reside in various tissues and travel around the body consuming harmful, damaged cells. They could make the heart valves paper-thin and hyper-efficient.
The new valve solves that problem by using naturally derived nanocomposites--a material assembled with a variety of very small components--including gels, vinyl, and cellulose. The combination of their new material with the non-invasive nature of transcatheter heart valves makes this new design very promising for use with high-risk patients, according to Mohammadi.
"Not only is the material important but the design and construction of our valve means that it lowers stress on the valve by as much as 40 percent compared to valves currently available," says Dylan Goode, a graduate researcher at the HVPL. "It is uniquely manufactured in one continuous form, so it gains strength and flexibility to withstand the circulatory complications that can arise following transplantation."
Working with researchers from Kelowna General Hospital and Western University, the valve will now undergo vigorous testing to perfect its material composition and design. The testing will include human heart simulators and large animal in-vivo studies. If successful, the valve will then proceed to clinical patient testing.
"This has the potential to become the new standard in heart valve replacement and to provide a safer, longer-term solution for many patients."
The new design was highlighted in a paper published in the Journal of Engineering in Medicine with financial support from the Natural Sciences and Engineering Research Council of Canada.
Source: Eurekalert
New Type of Immune Cells for Forming Heart Valves
New light on critical role of heart-derived macrophages has been shed by a research team from UCLA. Macrophages reside in various tissues and travel around the body consuming harmful, damaged cells. They could make the heart valves paper-thin and hyper-efficient.
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The new valve solves that problem by using naturally derived nanocomposites--a material assembled with a variety of very small components--including gels, vinyl, and cellulose. The combination of their new material with the non-invasive nature of transcatheter heart valves makes this new design very promising for use with high-risk patients, according to Mohammadi.
"Not only is the material important but the design and construction of our valve means that it lowers stress on the valve by as much as 40 percent compared to valves currently available," says Dylan Goode, a graduate researcher at the HVPL. "It is uniquely manufactured in one continuous form, so it gains strength and flexibility to withstand the circulatory complications that can arise following transplantation."
Working with researchers from Kelowna General Hospital and Western University, the valve will now undergo vigorous testing to perfect its material composition and design. The testing will include human heart simulators and large animal in-vivo studies. If successful, the valve will then proceed to clinical patient testing.
"This has the potential to become the new standard in heart valve replacement and to provide a safer, longer-term solution for many patients."
The new design was highlighted in a paper published in the Journal of Engineering in Medicine with financial support from the Natural Sciences and Engineering Research Council of Canada.
Source: Eurekalert
New Computer-designed Customized Regenerative Heart Valves Discovered
Computer-designed customized regenerative heart valve, an artificial heart valve which can grow, regenerate and predict computer simulations can be used in the treatment of valvular heart disease was successfully developed.
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 Scientists Design, Test Aortic Heart Valve ReplacementsAortic heart valve replacements made of polymers rather than animal heart tissues have been designed and tested by NIBIB-funded engineers. | Advertisement
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