Medindia
Advertisement

Scientists Design, Test Aortic Heart Valve Replacements

by Colleen Fleiss on February 24, 2019 at 5:17 PM

Scientists Design, Test Aortic Heart Valve Replacements
Aortic heart valve replacements made of polymers rather than animal heart tissues have been designed and tested by NIBIB-funded engineers.

The goal is to optimize performance of these valves in an effort to improve outcomes and enable increased use of a minimally-invasive method for valve replacement over the current practice of open heart surgery.
Advertisement


Aortic stenosis occurs when the aortic valve of the heart does not open fully as a result of Calcific Aortic Valve Disease (CAVD). CAVD is caused by calcium build up on the valve and can lead to heart failure. The condition affects more than 2.5 million people over the age of 75 in the U.S.1 For years, the valves have been replaced through open heart surgery: surgical aortic valve replacement (SAVR). However, increasingly, older patients who cannot tolerate surgery have been treated with a minimally-invasive procedure: transcatheter aortic valve replacement (TAVR), where a new valve compressed into a catheter is guided through a blood vessel and expanded on top of the diseased valve.

As the TAVR procedure and the design of the TAVR valves continues to be improved, more doctors and patients are opting for TAVR over surgery because the minimally-invasive nature of the procedure enables a dramatically decreased recovery time. Recovery from SAVR takes several months, while TAVR patients are typically out of the hospital and able to function normally within a few days.
Advertisement

However, the increase in use of TAVR in younger patients raises a serious issue of the durability of the valves as they are now expected to function for many more years in the patients' bodies. Longer term studies of TAVR procedures have identified potential degeneration and leakage problems with tissue-based valves currently used for TAVR.

Led by NIBIB grantee Danny Bluestein, Ph.D., Professor of Biomedical Engineering, Stony Brook University, NY, a team of experts in the dynamics of blood flow in the cardiovascular system has designed and laboratory tested an experimental polymer TAVR valve. The group hopes that the use of polymers will overcome some of the problems with long term use of tissue valves, improving the procedure and outcomes so that it can be reliably offered to more patients of all ages, reducing the need for open heart surgery.

"We are able to test the valves in the early stages of development using computer models and with mechanical devices that mimic the heart pumping blood through the valve," said Bluestein. "Our test systems and computer simulations allow us to evaluate a polymer valve and identify specific structural issues affecting performance. Then, we can make the necessary changes, for example in the shape, flexibility, or other aspects of the polymer that would mitigate problems and increase efficiency."

Bluestein explained that a key advantage of working with polymers is that unlike tissues, their shape and properties can be changed, allowing problems with devices to be rectified before moving into expensive animal testing.

Adds Grace Peng, Ph.D., director of the NIBIB program in Mathematical Modeling, Simulation, and Analysis, "Dr. Bluestein and his colleagues have been pioneers in combining mathematical modeling and experimental techniques to design and make real improvements in devices used to treat cardiovascular disorders. Their work is an outstanding example of how mathematical modeling and simulation approaches can accelerate the development and increase the reliability of medical treatments and devices that are life-saving for thousands of patients with serious diseases."

Source: Newswise
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Undescended Testicles Heart Varicocele Healthy Heart Statins Mitral Valve Prolapse Aortic Valve Stenosis Testicle Pain - Symptom Evaluation Pericarditis Torsion Testis 

Recommended Reading
U.S. FDA Approves LivaNova’s Perceval Sutureless Aortic Heart Valve
LivaNova, formed from the merger of Sorin and Cyberonics, has received FDA approval for its ......
Edwards Sapien 3 Prosthetic Aortic Heart Valve Gets FDA Approval In U.S, Europe
The device was designed to lower the chances of leakage around the valve, which should reduce ......
Stationary Cycling Test Could be Leading to Unnecessary Open Heart Operations
Exercise testing such as stationary cycling is used on people with a condition called aortic ......
Smaller Implanted Heart Valves Up Death Risk
Patients who underwent a minimally invasive, catheter-based approach to replace the aortic valve ......
Aortic Valve Stenosis
Aortic valve Stenosis is an abnormal narrowing of the c valve. Symptoms include angina, and that of ...
Mitral Valve Prolapse
Mitral Valve Prolapse is a relatively common condition and causes leakage of blood through the valve...
Pericarditis
Pericarditis occurs when the pericardium gets inflamed. Pericarditis is characterized by severe ches...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...
Testicle Pain - Symptom Evaluation
A sudden, severe pain in the testis may be due to testicular torsion. Testicles inside the scrotum a...
Torsion Testis
Torsion occurs when the testis spins, twisting the spermatic cord, causing reduced blood flow and te...
Undescended Testicles
An undescended testicle / testis is one that has not descended into the scrotal sac before birth. It...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use