Recent study has increased the number of genes linked to juvenile idiopathic arthritis (JIA) from three to seventeen.
Published April 21, the study involves an international research team that analyzed 2,816 JIA cases recruited from more than 40 pediatric rheumatology clinics. It was the largest collaborative patient population of JIA to date, including patient DNA samples from across the United States, Germany and United Kingdom, according to Susan Thompson, PhD, a researcher in the Division of Rheumatology at Cincinnati Children's Hospital Medical Center who was a leader for the study.
"These findings will help us understand how the long suspected genetic contributions to JIA are driving the disease process, with the ultimate goal being earlier and improved diagnosis and treatment," Thompson said.
Prior to the current study only three genes were associated with known JIA risk, although scientists have suspected the likelihood that more genes are involved. The research team used what is known as the Immunochip array to measure variation in the genes (DNA) coding for components of the immune system for 2,816 JIA patients in the study. Those findings were compared to the DNA of 13,000 healthy controls to look for genetic differences.
The analyses re-confirmed JIA's connection to the original three genes, identified a link to the 14 new genes and pointed to the possibility that another 11 genetic regions may be implicated. The scientists stressed that their work continues in order to identify additional genetic links and also begin conducting functional studies to pinpoint disease processes.
Although the current study substantially increases the number of confirmed susceptibility genes for JIA, the researchers said their data indicate that additional genetic risk factors still remain to be discovered.