A new non-toxic method developed helps deliver anti-cancer drugs effectively to specific parts of the body, where the severe and horrid side effects linked to cancer therapies can be reduced, reveals a new study.
Scientits at Cardiff University's School of Pharmacy and Pharmaceutical Sciences have developed the method, which involves the use of a new type of a nanotube, a tiny tube used in many applications, including drug delivery.
Target of Anticancer Drugs Have Broader Functions
Histone deacetylases (HDACs) are the drugs that inhibit the activity of enzymes. They are being widely developed for treating cancer and other diseases, with two already on the market.
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‘Nanotubes can improve delivery of anti-cancer drugs by reducing the spread of cancer and tumor growth, which can also lead to the development of effective cancer therapies.’
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This new type, designed and created by Dr Ben Newland at Cardiff University, is made from a non-toxic polymer called poly(ethylene glycol). Unlike current nanotubes, which can cause asbestos like toxicity, these new versions are soft, flexible and biocompatible, meaning they should be well tolerated by the body.
It's thought that not only could the development of this new nanotube provide a better way of delivering anti-cancer drugs, it could lead to far less side effects too.
![Cisplatin-Resistant Cancer Cells Sensitive To Anticancer Drugs: Research]( "Cisplatin-Resistant Cancer Cells Sensitive To Anticancer Drugs: Research")
For cancer patients, poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy, that has become resistant to the commonly used chemotherapy drug cisplatin.
That's because, currently, many drugs used in chemotherapy to treat various forms of cancer are administered through an injection into the blood stream. Although these drugs reach cancer cells, they also negatively impact on perfectly healthy cells causing an array of harsh side-effects including hair loss, sickness and extreme fatigue.
The new nanotube has the potential to be injected into a specific part of the body, which means the rest of the body is left largely unaffected by the toxic anti-cancer drugs.
To explore this further, research looking at how effective this new nanotube could be in treating breast cancer was carried out. A drug called Doxorubicin was administered through the nanotube and was compared to the same dose of the same drug being injected into the bloodstream.
The findings revealed a reduction in both the rate of metastasis (cancer spreading) and the rate of tumor growth through the nanotube delivery method, giving the research team hope that the development of the new nanotube could lead to more effective cancer therapies in the future.
Speaking of these findings, Cardiff University's Dr Ben Newland commented: "With the development of a brand new type of nanotube, we are in unchartered territory. We are in the early stages of this research, but it's exciting to think about the potential improvements in the way that drugs are delivered."
The research project is a collaboration between Cardiff University's School of Pharmacy and Pharmaceutical Sciences, the Leibniz Institute of Polymer Research in Dresden and the University of Strathclyde and has been funded by the Welcome Trust.
Full details of the findings of this research are published in an article entitled 'Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery ' in the journal Nanoscale.
Source: Eurekalert
Cisplatin-Resistant Cancer Cells Sensitive To Anticancer Drugs: Research
For cancer patients, poly (ADP-ribose) polymerase inhibitors may be a novel treatment strategy, that has become resistant to the commonly used chemotherapy drug cisplatin.
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That's because, currently, many drugs used in chemotherapy to treat various forms of cancer are administered through an injection into the blood stream. Although these drugs reach cancer cells, they also negatively impact on perfectly healthy cells causing an array of harsh side-effects including hair loss, sickness and extreme fatigue.
The new nanotube has the potential to be injected into a specific part of the body, which means the rest of the body is left largely unaffected by the toxic anti-cancer drugs.
To explore this further, research looking at how effective this new nanotube could be in treating breast cancer was carried out. A drug called Doxorubicin was administered through the nanotube and was compared to the same dose of the same drug being injected into the bloodstream.
The findings revealed a reduction in both the rate of metastasis (cancer spreading) and the rate of tumor growth through the nanotube delivery method, giving the research team hope that the development of the new nanotube could lead to more effective cancer therapies in the future.
Speaking of these findings, Cardiff University's Dr Ben Newland commented: "With the development of a brand new type of nanotube, we are in unchartered territory. We are in the early stages of this research, but it's exciting to think about the potential improvements in the way that drugs are delivered."
The research project is a collaboration between Cardiff University's School of Pharmacy and Pharmaceutical Sciences, the Leibniz Institute of Polymer Research in Dresden and the University of Strathclyde and has been funded by the Welcome Trust.
Full details of the findings of this research are published in an article entitled 'Soft and flexible poly(ethylene glycol) nanotubes for local drug delivery ' in the journal Nanoscale.
Source: Eurekalert
Neural Network is well trained to Select New Anticancer Drugs
A neural network that selects potential anticancer drugs, developed by a research team from Medicine and Moscow Institute of Physics and Technology (MIPT).
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 Research Sheds Light on Harnessing Anticancer Drugs for the Future Fight Against InfluenzaA new cell screening method that can be used to identify potential anti-influenza drugs has been developed by the Medical Systems Virology group | Advertisement
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