A new cell screening method that can be used to identify potential anti-influenza drugs has been developed by the Medical Systems Virology group at the Institute for Molecular Medicine Finland (FIMM) at the University of Helsinki and its national and international collaborators.
The researchers were able to identify two novel compounds with anti-influenza activity, obatoclax and gemcitabine and prove the efficacy of a previously known drug saliphenylhalamide.
The study was recently accepted for publication in the Journal of Biological Chemistry and is now available online.
"An interesting aspect of this study is that the antiviral effects of obatoclax, saliphenylhalamide and gemcitabine, which all are either investigational or approved anticancer agents, are achieved at much lower concentrations than that needed to mediate cancer cell death" said the group leader Denis Kainov.
However, further research is still needed before these drugs can be clinically tested and applied in influenza infections.
This research project is a good example of repurposing of drugs, i.e. finding new applications for existing drugs and thus saving money and time on drug development.
"We anticipate that these types of drugs could in the future reinforce the therapeutic arsenal and address the needs of the society to control influenza outbreaks", said Olli Kallioniemi, the Director of FIMM.