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New Drugs Could Treat Dangerous Blood Clots Better After Hip Replacement Surgery

by Tanya Thomas on January 14, 2011 at 7:38 AM
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 New Drugs Could Treat Dangerous Blood Clots Better After Hip Replacement Surgery

Scientists have suggested that two new drugs - Apixaban and Rivaroxaban - might be more effective and easier to use than commonly used medicines in preventing dangerous blood clots after hip replacement surgery.

The results reveal a better way to prevent the formation of blood clots in the deep veins of the legs - a condition known as deep vein thrombosis (DVT).

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The blood clots become life-threatening pulmonary embolisms (PE) when they break free and travel to the lungs.

The study compared the drug Apixaban, given orally twice a day, to the current standard medicine Enoxaparin, given twice daily by injection under the skin.
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The randomized, double-blind trial involved more than 5,000 patients and showed Apixaban reduced the risk of blood clots, without increasing bleeding side effects.

"Each year, about 750,000 Americans undergo hip or knee replacement surgery and that number is growing rapidly. This is a major stride forward as we work toward better prevention of life-threatening blood clots in these patients," said Gary Raskob, dean of University of Oklahoma College of Public Health.

He said that the development of new oral anticoagulant agents, like Apixaban, has raised hope of a standard of care for DVT prevention that is as effective as or more effective than current standard approaches as well as being equally safe and more convenient for patients.

Raskob also was a primary author in another study published in the same issue of The New England Journal of Medicine focusing on the treatment of patients with established deep vein thrombosis.

"Despite the best current prevention efforts, blood clots still occur. So, it is important to continue to work toward better treatments as well as better ways to prevent blood clots," he said.

The second clinical trial, which included patients at the University of Oklahoma Health Sciences Centre, found that the medication Rivaroxaban provided a simple, effective, single-drug approach for both short-term and continued long-term treatment of patients with deep vein thrombosis.

Rivaroxaban is given orally in a fixed dose without the need for laboratory blood testing to monitor the anti-clotting effect.

Current treatment methods, on the other hand, use two drugs, one given by injections under the skin once or twice a day for 5 to 10 days, followed by an oral medication that requires careful monitoring and dose adjustment based on results of regular blood tests.

Scientists at OU and their colleagues worldwide are working diligently to find better and more practical tools to prevent and treat blood clots in the legs and lungs.

The study is published in The New England Journal of Medicine.

Source: ANI
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