Researchers have offered new hope to patients with end-stage liver disease. Transplanting their own (autologous) bone marrow-derived stem cells into 48 patients with end-stage liver disease resulted in therapeutic benefit to a high number of the patients. Yet, the mechanism by which the infusion of CD34 stem cells improves liver function remains elusive, they said. According to the study's corresponding author, Mark A. Zern of the University of California Davis Medical Center, Sacramento, CA, the study sought to evaluate the safety and efficacy of transplanting autologous bone marrow-derived CD34+ stem cells in 48 patients, 36 of whom had chronic, end-stage hepatitis C-induced liver disease, and 12 with end-stage autoimmune liver disease. "For all patients there was a statistically significant decrease in peritoneal cavity fluid, or 'ascites.' There was also clinical and biochemical improvement in a large percentage of patients who received the transplantation," said Zern. The researchers reported that they obtained "reasonable numbers of CD34+ cells" that were then "amplified and partially differentiated into hepatocyte precursor cells." "This enabled us to transplant as many as one billion of these cells per patient. The finding of improvement in ascites in a significant number of patients is impressive and somewhat urprising, suggesting that cell transplantation might be clinically significant beyond the improvement in laboratory parameters," explained Zern. The team also reported that prior to transplantation, the cells were already beginning to develop a hepatocyte phenotype while in culture, suggesting that the cells may have acted as hepatocyte-like cells following engraftment. The findings were reported in the journal Cell Transplantation. Source: ANI << New Drugs Could Treat Dangerous Blood Clots Better After Hi... Women With Chlamydia At Greater Risk of Ectopic Pregnancy >> Recommended Reading Alcoholic Liver Disease Encyclopedia section of medindia gives general information about Alcoholic Liver Disease. READ MORE Current Treatments for Liver Cancer Current Treatments for Liver Cancer (also known as hepatoma or hepatocellular carcinoma) can result in complete cure of the disease if it is detected early. READ MORE Fatty Liver Disease: A Growing Health Problem in India Non alcoholic fatty liver disease (NAFLD) is the leading cause of liver dysfunction worldwide and is a rapidly growing health problem in India. READ MORE Hepatitis A Hepatitis A is the most benign of the hepatitis viruses and usually has no long term side effects. Hepatitis A vaccine is available that is 95% effective in preventing the disease. READ MORE Living Donor Liver Transplant: What Are the Risks? The risk of dying as a result of a living donor liver segment removal is between 0.2-2.0%. The risk of morbidity is anywhere between 1.3% (in highly experienced centers) to 60%. READ MORE Milk Thistle Milk Thistle is a resourceful natural plant which has many medicinal benefits. In herbal medication milk thistle is used in cases of liver diseases. READ MORE Wilson's Disease This is a rare inherited systemic disorder of copper metabolism, affecting the liver mainly before other organs. READ MORE Most Popular on Medindia Find a Doctor Blood Pressure Calculator Drug - Food Interactions More News on: Alcoholic Liver DiseaseLiver BiopsyHepatitis ALiverWilson's DiseaseMilk ThistleCurrent Treatments for Liver CancerFatty Liver Disease: A Growing Health Problem in IndiaLiving Donor Liver Transplant: What Are the Risks?