Salk researchers have made a diet pill, called fexaramine, which tricks your body into thinking you just ate, causing it to burn fat. Unlike most diet pills in the market, this new pill does not dissolve into the blood like appetite suppressants or caffeine-based diet drugs, but remains in the intestines, causing fewer side effects and is better at stopping weight gain.
During the study obese mice were given a daily pill of fexaramine for five weeks. Mice studies revealed that the compound effectively stopped weight gain, lowered cholesterol, controlled blood sugar and minimized inflammation in mice, making it an excellent candidate for a rapid transition into human clinical trials. In addition, the mice had a rise in body temperature which signals metabolism going up and some deposits of white fat in their bodies converted into a healthier, energy-burning beige form of the tissue. Even the collection of bacteria in the guts of mice shifted when they received the drug, although scientists are yet to determine what those changes mean.
Senior author of the paper, Ronald Evans, said, "The pill is like an imaginary meal, and sends out the same signals that normally happen when a person eats a lot of food, so the body starts clearing out space to store it. But there are no calories and no change in appetite."
The study is published in 'Nature Medicine'.