Multigene test that is currently used to avoid unnecessary breast cancer treatment is really making a difference, finds a new study. It was found that this test did, in fact, provides useful input when deciding on chemotherapy.
Multigene tests have been used in breast cancer treatment to assess the risk of metastasis for several years. A team at the Breast Cancer Center at the Technical University of Munich's (TUM) Klinikum rechts der Isar has now presented results based on data collected in its routine clinical work. These results show that the multigene test used at the university hospital is indeed helpful in making more targeted use of chemotherapy treatments and thus improves the prognosis of breast cancer patients.
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‘Currently Multigene tests are being used in breast cancer treatment to assess the risk of cancer spread (metastasis). This test helpfully provides input when a doctor needs to decide on chemotherapy.’
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Since November 2011, the Gynecological Clinic at Klinikum rechts der Isar has used a multigene test for patients with early hormone receptor-positive, HER2-negative breast cancer. Using tissue samples and other clinical indicators, the test helps to determine a patient's risk of metastasis.
"Based on the test results, which combine molecular biological properties of the tumor along with the individual factors of tumor size and the presence of cancer in lymph nodes, doctors decide whether chemotherapy is recommended in addition to the surgical removal of the tumor followed by anti-hormone treatment," explains Prof. Marion Kiechle, the Director of the Gynecological Clinic. "In case of a low metastasis risk, chemotherapy may place an unnecessary burden on the patient. But in case of a high risk, it may prevent tumors from relapsing later."
![PET Tracer Enhances Breast Cancer Treatment]( "PET Tracer Enhances Breast Cancer Treatment")
Using a positron emission tomography (PET) tracer, researchers in the Netherlands have been able to identify differences in ER expression, which could help guide treatment for metastatic breast cancer patients.
At the San Antonio Breast Cancer Symposium in the USA, one of the world's most important congresses in that field, Dr. Johannes Ettl, Head Physician of the Gyneco-Oncological Outpatient Clinic, Technical University of Munich, Germany has now presented the results of an independent study not commissioned by a test manufacturer of the test used at the Breast Center.
373 patients tested
For the study, Dr. Ettl and his team tracked 373 breast cancer patients from the start of initial treatment and the related multigene test. The test indicated a low risk for 238 patients (63.8%) and a high risk for 135 (36.2%). After a median follows up of 3.5 years, the risk for disease recurrence was twice as high in the high-risk group as in the low-risk group. Similarly, high-risk patients were at five-fold increased risk of developing metastases in other organs. The low-risk and high-risk patients who received chemotherapy in addition to anti-hormone tablets had three-year disease free survival rates of 96.6% and 96.3%, respectively. By contrast, for high-risk patients who did not receive chemotherapy despite the doctors' recommendation based on the test results, the rate was only 91.5%.
"Our health care study has delivered the first data from routine clinical practice indicating that the test does, in fact, provide useful input when deciding on chemotherapy," says Prof. Kiechle. "Gene signature tests are important tools that help us to make more targeted use of chemotherapy treatments, both by limiting unnecessarily stressful treatments and avoiding the potentially serious consequences of rejecting chemotherapy in case of high metastasis risks."
Source: Eurekalert
PET Tracer Enhances Breast Cancer Treatment
Using a positron emission tomography (PET) tracer, researchers in the Netherlands have been able to identify differences in ER expression, which could help guide treatment for metastatic breast cancer patients.
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At the San Antonio Breast Cancer Symposium in the USA, one of the world's most important congresses in that field, Dr. Johannes Ettl, Head Physician of the Gyneco-Oncological Outpatient Clinic, Technical University of Munich, Germany has now presented the results of an independent study not commissioned by a test manufacturer of the test used at the Breast Center.
373 patients tested
For the study, Dr. Ettl and his team tracked 373 breast cancer patients from the start of initial treatment and the related multigene test. The test indicated a low risk for 238 patients (63.8%) and a high risk for 135 (36.2%). After a median follows up of 3.5 years, the risk for disease recurrence was twice as high in the high-risk group as in the low-risk group. Similarly, high-risk patients were at five-fold increased risk of developing metastases in other organs. The low-risk and high-risk patients who received chemotherapy in addition to anti-hormone tablets had three-year disease free survival rates of 96.6% and 96.3%, respectively. By contrast, for high-risk patients who did not receive chemotherapy despite the doctors' recommendation based on the test results, the rate was only 91.5%.
"Our health care study has delivered the first data from routine clinical practice indicating that the test does, in fact, provide useful input when deciding on chemotherapy," says Prof. Kiechle. "Gene signature tests are important tools that help us to make more targeted use of chemotherapy treatments, both by limiting unnecessarily stressful treatments and avoiding the potentially serious consequences of rejecting chemotherapy in case of high metastasis risks."
Source: Eurekalert
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Enzyme TLK2 shows reduced levels of activity in intellectual disability and that it is possible to inhibit it in breast cancer, where it is overactive.
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 New Insight into Mechanism of Breast Cancer Treatment ResistanceEstrogen receptor-positive (ER+) breast cancer uses the new specific mechanism to prevent metastasis that generally shows resistant to standard cancer therapies. | Advertisement
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