Insulin that is not delivered to the muscles and abnormal immunoglobulins increase blood sugars levels leading to diabetes and other complications.
Fighting Diabesity with Lifestyle Changes
With more than one billion people affected, diabesity is the largest epidemic in the world today. Fortunately it can be reversed with lifestyle changes.
With more than one billion people affected, diabesity is the largest epidemic in the world today. Fortunately it can be reversed with lifestyle changes.
‘Nondelivery of insulin to the muscles and abnormal immunoglobulins increase blood sugars levels leading to diabetes and other complications like cardiovascular, kidney and vision problems.
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Researchers found that in obesity, insulin released into the blood by the pancreas is unable to pass through the cells that form the inner lining of blood vessels. As a result, insulin is not delivered to the muscles, where it usually stimulates most of the body's glucose to be metabolized. Blood glucose levels rise, leading to diabetes and its related cardiovascular, kidney and vision problems, said Dr. Philip Shaul, Director of the Center for Pulmonary and Vascular Biology in the Department of Pediatrics at UT Southwestern.
"It was totally unpredicted that a major problem in obesity is the delivery of circulating insulin to your muscle. It was even more surprising that this problem involves immunoglobulins, which are the proteins that make up circulating antibodies," said Dr. Chieko Mineo, Associate Professor of Pediatrics, who is a co-senior author on the report with Dr. Shaul.
Way to Manipulate Protein Linked With Obesity and Diabetes Identified
A new study published in the journal Nature Medicine reveals that by UT Southwestern Medical Center researchers have managed to find ways through which they can manipulate mitoNEET protein.
A new study published in the journal Nature Medicine reveals that by UT Southwestern Medical Center researchers have managed to find ways through which they can manipulate mitoNEET protein.
"The abnormal immunoglobulins then act on cells lining blood vessels to inhibit an enzyme needed to transfer insulin from the bloodstream into the muscle," said Dr. Shaul, who holds the Associates First Capital Corporation Distinguished Chair in Pediatrics.
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Mexican President Asks His Countrymen to Exercise More to Fight Obesity and Diabetes
Mexican President Enrique Pena Nieto launched a new campaign against rising obesity and diabetes rates in the country, asking his citizens to walk more, use stairs and exercise one hour every day.
Mexican President Enrique Pena Nieto launched a new campaign against rising obesity and diabetes rates in the country, asking his citizens to walk more, use stairs and exercise one hour every day.
The findings reported in The Journal of Clinical Investigation may lead to new tools for diabetes risk screening and new avenues for diabetes prevention or treatment.
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New Attempt to Treat Obesity and Diabetes Identifies Hormone Mix That Reduces Appetite, Obesity
In an attempt to treat obesity and diabetes, scientists have identified a new treatment that uses the joint effect of two hormones, important in metabolism, to reduce appetite.
In an attempt to treat obesity and diabetes, scientists have identified a new treatment that uses the joint effect of two hormones, important in metabolism, to reduce appetite.
The researchers plan to test this strategy in humans in the near future.
Source-Eurekalert
