About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Most Crucial Link Between Obesity and Diabetes Identified

by Hannah Joy on November 30, 2017 at 5:00 PM
Font : A-A+

Most Crucial Link Between Obesity and Diabetes Identified

A major mechanism has been identified by which obesity causes type 2 diabetes. Insulin that is not delivered to the muscles raises the blood glucose levels leading to diabetes, reveals a new study.

Type 2 diabetes is a common complication of being overweight that afflicts more than 30 million Americans and over 400 million people worldwide, said UT Southwestern researchers.

Advertisement


Researchers found that in obesity, insulin released into the blood by the pancreas is unable to pass through the cells that form the inner lining of blood vessels. As a result, insulin is not delivered to the muscles, where it usually stimulates most of the body's glucose to be metabolized.

Blood glucose levels rise, leading to diabetes and its related cardiovascular, kidney and vision problems, said Dr. Philip Shaul, Director of the Center for Pulmonary and Vascular Biology in the Department of Pediatrics at UT Southwestern.
Advertisement

"It was totally unpredicted that a major problem in obesity is the delivery of circulating insulin to your muscle. It was even more surprising that this problem involves immunoglobulins, which are the proteins that make up circulating antibodies," said Dr. Chieko Mineo, Associate Professor of Pediatrics, who is a co-senior author on the report with Dr. Shaul.

The researchers found that obese mice have an unexpected chemical change in their immunoglobulins.

"The abnormal immunoglobulins then act on cells lining blood vessels to inhibit an enzyme needed to transfer insulin from the bloodstream into the muscle," said Dr. Shaul, who holds the Associates First Capital Corporation Distinguished Chair in Pediatrics.

"Type 2 diabetes patients have the same chemical change, and if we give a mouse immunoglobulins from a type 2 diabetic individual, the mouse becomes diabetic."

The findings reported in The Journal of Clinical Investigation may lead to new tools for diabetes risk screening and new avenues for diabetes prevention or treatment.

The researchers identified an agent that they could administer to mice that prevents the chemical change in immunoglobulins that occurs with obesity and preserves healthy glucose status.

The researchers plan to test this strategy in humans in the near future.



Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
First-Ever Successful Pig-To-Human Kidney Transplantation
World Osteoporosis Day 2021 -
Spirituality and Mental Health
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Diabetic Retinopathy Obesity Diabetes Diabetic Diet Diabetes - Essentials Bulimia Nervosa Diabetes - Self-Monitoring of Blood Glucose (SMBG) Insulin Delivery Devices Diabetes and Exercise 

Recommended Reading
Diabesity
With more than one billion people affected, diabesity is the largest epidemic in the world today. .....
Way to Manipulate Protein Linked With Obesity and Diabetes Identified
A new study published in the journal Nature Medicine reveals that by UT Southwestern Medical Center ...
Mexican President Asks His Countrymen to Exercise More to Fight Obesity and Diabetes
Mexican President Enrique Pena Nieto launched a new campaign against rising obesity and diabetes ......
New Attempt to Treat Obesity and Diabetes Identifies Hormone Mix That Reduces Appetite, Obesity
In an attempt to treat obesity and diabetes, scientists have identified a new treatment that uses .....
Bulimia Nervosa
The term ''Bulimia'' refers to episodes of uncontrolled excessive eating, known as "binges," followe...
Diabetes
A comprehensive article on diabetes - both Type 1 and Type 2 diabetes, including : causes, signs, sy...
Diabetes - Essentials
Diabetes is a metabolic disease caused by insulin deficiency that leads to high blood sugar levels a...
Diabetes - Self-Monitoring of Blood Glucose (SMBG)
Self-Monitoring Of Blood Glucose (SMBG) is one of the greatest advancements in the management of Di...
Diabetes and Exercise
Regular exercise especially in type II diabetes not only helps reduce the sugar but also reduces the...
Diabetic Diet
The diabetic diet most often recommended is high in dietary fiber (especially soluble fiber) and nut...
Diabetic Retinopathy
The term ‘diabetic retinopathy’ refers to changes in the retina which often occur in people with ......
Insulin Delivery Devices
Insulin delivery devices have evolved drastically since their invention in 1922. They are all aimed ...
Obesity
Obesity is a condition where there is excess accumulation of body fat which poses a risk to the heal...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use