Mifepristone Extends the Life Span of Female Fruit Flies by 68 Percent

by Dr. Trupti Shirole on February 6, 2015 at 10:59 AM

 Mifepristone Extends the Life Span of Female Fruit Flies by 68 Percent
Researchers at the USC Dornsife College of Letters, Arts and Sciences have discovered that a synthetic and commonly used laboratory chemical, mifepristone, can extend the life span of female fruit flies by 68 percent.

For several years, scientists have engineered fruit flies whose genes can be turned on and off by a synthetic hormone, allowing detailed studies of the effects of single genes on life span. Interestingly, many of the genes have close relatives in humans.

Researcher John Tower and Gary Landis grew suspicious of the hormone mifepristone that they and others were using to activate the genes. It is a synthetic chemical known to terminate pregnancy in humans. Previous studies have shown that reproduction shortens lifespan in flies and other organisms and so researchers wondered if the hormone they were using could be affecting reproduction in flies, and in turn their life span.

They found that flies exposed to the hormone laid only half the usual amount of eggs and lived 68 percent longer, from a median age of 56 to 94 days. They also found that mifepristone had little or no effect on the life expectancy of female flies that had not mated, which had an even better overall survival rate and maximum lifespan.

Tower added, "This opens up a new line of inquiry for longevity studies, and identifies candidate genes and mechanisms for regulating the trade-off between reproduction and lifespan that may be shared with humans. It does, however, mean that their earlier longevity studies that relied on mifepristone as a gene switch will need to be reevaluated."

The findings are published online in the journal Aging.

Source: Medindia

News A-Z
News Category
What's New on Medindia
'Hybrid Immunity' may Help Elude COVID-19 Pandemic
Stroop Effect
Plant-Based Diet may Reduce the Risk of COVID-19
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Why Do We Eat - Nutrition Facts Diet Lifestyle and Heart Disease The Acid-Alkaline balance, Diet and Health Nails - Health and Disease Fruits to Help Lower Blood Pressure Health benefits of bananas Fruitarian Diet Papaya Brand-Food Rules for the New Year Health Benefits of Pineapple 

Recommended Reading
Eat Right and Beat Those Wrinkles - Foods that Cause Aging
Bad eating habits will affect your health as well as your skin and make you look older than your ......
Anti-aging Secrets to a Younger You
Is there anyone in this world who fails to be swayed by the magic of youth? None, for when youth ......
Anti-Aging Treatment with Vinotherapy or Wine Facials
Experience the bliss of vinotherapy - the power of grapes for a kissable skin....
Signature of Aging Exist Solely in the Brain: Study
Researchers have identified signature of aging in the brain, suggesting the possibility of slowing ....
Brand-Food Rules for the New Year
With the increasing awareness and emphasis on diet and food, here’s a new list of rules. Stick to th...
Fruitarian Diet
Fruitarian diet is composed of more than 50 percent of fruits. A variety of fruits can be included i...
Fruits to Help Lower Blood Pressure
Top reasons why you should eat fruits to lower blood pressure and reduce the risk of heart disease. ...
Health Benefits of Pineapple
Pineapples consumed by and large by people all over the world are a rich source of Vitamin C and hav...
Nails - Health and Disease
Nail changes could indicate a health problem or a disease condition. Read more to know about what yo...
Papaya, is not only nutritious; it has numerous medicinal benefits as well. The leaves, seeds and th...
Why Do We Eat - Nutrition Facts
The importance of eating food and the physiological, psychological and social functions of food....

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use