About Careers MedBlog Contact us

Mifepristone Extends the Life Span of Female Fruit Flies by 68 Percent

by Dr. Trupti Shirole on February 6, 2015 at 10:59 AM
Font : A-A+

 Mifepristone Extends the Life Span of Female Fruit Flies by 68 Percent

Researchers at the USC Dornsife College of Letters, Arts and Sciences have discovered that a synthetic and commonly used laboratory chemical, mifepristone, can extend the life span of female fruit flies by 68 percent.

For several years, scientists have engineered fruit flies whose genes can be turned on and off by a synthetic hormone, allowing detailed studies of the effects of single genes on life span. Interestingly, many of the genes have close relatives in humans.


Researcher John Tower and Gary Landis grew suspicious of the hormone mifepristone that they and others were using to activate the genes. It is a synthetic chemical known to terminate pregnancy in humans. Previous studies have shown that reproduction shortens lifespan in flies and other organisms and so researchers wondered if the hormone they were using could be affecting reproduction in flies, and in turn their life span.

They found that flies exposed to the hormone laid only half the usual amount of eggs and lived 68 percent longer, from a median age of 56 to 94 days. They also found that mifepristone had little or no effect on the life expectancy of female flies that had not mated, which had an even better overall survival rate and maximum lifespan.

Tower added, "This opens up a new line of inquiry for longevity studies, and identifies candidate genes and mechanisms for regulating the trade-off between reproduction and lifespan that may be shared with humans. It does, however, mean that their earlier longevity studies that relied on mifepristone as a gene switch will need to be reevaluated."

The findings are published online in the journal Aging.

Source: Medindia


Recommended Reading

Latest Anti-Aging News

Fight Off Aging by Improving Your Body's Anti-Viral Immune Response
Aging, or senescent cells, which stop dividing but don't die, can accumulate in the body over the years and fuel chronic inflammation.
Why Do People With Mental Illness Have Appearances Older Than Their Actual Age?
Prolonged mental health disorders namely depression, anxiety put individuals at shorter life span and age-related diseases risk.
Eating Less May Slow Down Aging in Healthy Adults
Does a low-calorie diet slow aging? Yes, eating fewer calories while maintaining optimal nutrition, may slow down aging and increase life span.
 Repeated Blows to the Head may Knock Out Brain Function Later
Can multiple concussions affect you later in life? Repeated head injuries slowly get worse over time and lead to declining brain function in old age.
Anti-Aging Skin Care: Hyaluronic Acid can Keep Signs of Aging at Bay
Secret solution for anti-aging: Hyaluronic acid can help you stop the signs of aging like wrinkles, skin thinning and loss of skin elasticity.Start HA treatment today to stay young
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close

Mifepristone Extends the Life Span of Female Fruit Flies by 68 Percent Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests