New study conducted by scientists shows how MRSA regulates the critical crosslinking of its cell wall in the face of beta-lactam antibiotics.
Modern strains of MRSA have become broadly resistant to antibiotics, including beta-lactam antibiotics, such as penicillins.
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become life-threatening.
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In their report, the researchers disclose the discovery of an allosteric domain in the X-ray structure of the penicillin binding protein 2a of MRSA, the enzyme that carries out the crosslinking reaction.
The researchers documented that an allosteric trigger by a fragment of the cell wall at a distance of 60 Angstroms (6 nanometers) activates a set of conformational changes that culminates in the opening of the active site from a closed conformation, enabling catalysis for the physiological role of the enzyme.
![Drug Resistance - Antibiotic Resistance]( "Drug Resistance - Antibiotic Resistance")
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.
They also documented that the new beta-lactam antibiotic ceftaroline, recently approved by the Food and Drug Administration, is able to bind to the allosteric domain and trigger the same allosteric opening of the active site. This subversion of the allosteric control allows another molecule of ceftaroline to access the active site, which inhibits the function of the enzyme, leading to cell death by MRSA.
The study is published in the Proceedings of the National Academy of Sciences.
Source: ANI
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and hospital acquired diseases. Judicious use of antibiotics can control the problem.
Advertisement
They also documented that the new beta-lactam antibiotic ceftaroline, recently approved by the Food and Drug Administration, is able to bind to the allosteric domain and trigger the same allosteric opening of the active site. This subversion of the allosteric control allows another molecule of ceftaroline to access the active site, which inhibits the function of the enzyme, leading to cell death by MRSA.
The study is published in the Proceedings of the National Academy of Sciences.
Source: ANI
Scientists Discover A Potential New Target to Thwart Antibiotic Resistance
A team of Wyss Institute scientists has found that bacteria in the gut that are under attack by antibiotics have allies no one had anticipated.
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 Biosensor That can Detect Antibiotic Resistance in Superbugs DevelopedIn a major breakthrough that can help identify and treat superbug infections, researchers have developed a new biosensor through which they can detect antibiotic resistance in bacteria. | Advertisement
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