At ITbM, Nagoya University, researchers developed a new nickel catalyst with a "Kabuto-like" structure.
It was found to catalyze the cross-coupling reaction between carbonyl compounds and readily available phenol derivatives, to form alpha-arylketones, which are found in many biologically active compounds (Kabuto = a helmet worn by Japanese samurai).
Nagoya, Japan - Professors Kenichiro Itami and Junichiro Yamaguchi of the Institute of Transformative Bio-Molecules (WPI-ITbM) and graduate students Ryosuke Takise and Kei Muto of Nagoya University have succeeded in developing a novel nickel catalyst to catalyze the cross-coupling reaction between carbonyl compounds and phenol derivatives.
Cross-coupling reactions catalyzed by transition metals enables direct formation of carbon-carbon bonds, which is widely utilized in the formation of a vast number of organic frameworks. This strategy that won the 2010 Nobel Prize in Chemistry extends to alpha-arylation reactions, which allows incorporation of aromatic rings into carbonyl compounds through carbon-carbon bond formation, mainly using palladium as a catalyst. Many organic molecules such as amino acids contain carbonyl groups. Thus, alpha-arylation, which links carbonyl compounds to aromatic rings present in an array of organic molecules, has been used as one of the main reactions to create the organic backbone of many pharmaceuticals and organic materials.
Professors Itami and Yamaguchi along with co-workers have been working to develop a new economical catalyst to conduct alpha-arylation reactions using readily available phenol derivatives as starting materials. This reaction system is envisaged to lead to the facile production of alpha-arylketones on an industrial scale.