Environmentally-friendly iron-based nanoparticle catalysts promise the synthesis of greener and cheaper drugs, say chemists.
"It is always important to strive to make industrial syntheses more green, and using iron catalysts is not only much less toxic, but it is also much more cost effective," said Jessica Sonnenberg, a PhD student and lead author of a paper published this week in the Journal of the American Chemical Society.
The research, which was directed by Robert Morris, chair of the Department of Chemistry, involved several steps. Suspecting the existence of nanoparticles, the team first set out to identify the iron catalysts. They then conducted investigations using an electron microscope to confirm that the iron nanoparticles were actually being formed during catalysis. The next step was to ensure that the iron nanoparticles were the active catalytic agents. This was done with polymer and poisoning experiments which showed that only the iron atoms on the surface of a nanoparticle were active.