Is FOXP4 the Drama Queen Behind Long COVID?

Just when we thought the worst of the pandemic was over, Long COVID entered the scene—haunting many people long after their infection cleared. From brain fog to breathlessness, the symptoms linger like a shadow. But now, scientists have made a breakthrough: they’ve discovered that your genes, especially one called FOXP4, could be behind this mystery. What does this mean? Your DNA might be holding secrets to how your body responds to the virus—even months later. The discovery offers a new ray of hope for understanding, treating, and perhaps one day preventing Long COVID (1^✔ ✔Trusted Source
Genome-wide association study of long COVID

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FOXP4 – The Lung Gene That Won’t Stay Quie

A gene called FOXP4, helps control lung function, might also play a big part in Long COVID. People with a certain version of this gene are more likely to have lingering symptoms, even after mild infections. FOXP4 doesn’t just sit quietly—it gets overactive in the lungs and immune cells, especially in people with long-term COVID effects. This gene may keep inflammation going, even when the virus is gone. Understanding this gives doctors a target to treat.

Not Just the Lungs—It’s Also in Your Head

Long COVID isn’t just about coughs and tiredness. Many people say they feel like their brain is stuck in a fog—forgetful, slow, or confused. That’s because the FOXP4 gene also affects the brain. Scientists found that it’s active in areas like the hypothalamus, which manages your sleep, mood, and energy. This explains why long COVID can feel like you’re not yourself anymore.

Why This Discovery Matters to You

You might wonder—why should I care about genes and research papers? Because this discovery could help doctors predict who is at risk for Long COVID. It could lead to gene-based tests, better recovery plans, or even new treatments. Plus, if you or someone you love is still struggling after COVID, you now know it’s not “in your head”—it’s in your genes and lungs. This isn’t just science; it’s hope wrapped in data. And that’s the kind of news worth reading—and sharing.

Reference:

1. Genome-wide association study of long COVID - (https://www.nature.com/articles/s41588-025-02100-w)

Source-Karolinska Institutet