Medindia LOGIN REGISTER
Medindia
Advertisement

Insight into Blood Signatures of Inflammation

by Colleen Fleiss on May 15, 2018 at 2:15 AM
 Insight into Blood Signatures of Inflammation

Pattern of inflammation associated with cardio-metabolic risks among participants in the Black Women's Health Study, as well as two independent groups of vulnerable women has been identified in a new study from Boston University Schools of Medicine (BUSM) and Public Health (BUSPH). These findings could help underserved patients benefit from precision medicine and personalized profiles of disease risk.

According to the researchers, body mass index alone is an imperfect measure of obesity-associated disease risks, such as for Type 2 diabetes, because there are some individuals with chronic obesity who are apparently protected from cardio-metabolic complications and lean individuals with high cardiovascular and diabetes risks. Certain biomarkers show promise in predicting obesity-associated diabetes risk; however, the clinical utility of single biomarkers is limited for complex disease phenotypes such as these. The research team took a data-driven, systems biology approach to discover six cytokine signatures associated with Type 2 diabetes risk in a vulnerable population: African American women with obesity and varying degrees of metabolic health. These six distinct signatures are patterns of sixteen cytokines/chemokines that promote or reduce inflammation.

Advertisement


Analyses of plasma samples from participants in the Black Women's Health Study, formed the basis for the discovery dataset, which was then validated in two separate groups, African American women volunteers with obesity who had donated plasma to the Komen Tissue Bank, and African American women with obesity who were breast reduction surgical patients at a safety net hospital in Greater Boston. The patterns or signatures in the validation cohorts closely resembled the distributions in the discovery cohort. "These findings are highly relevant to an understudied and underserved population that experiences elevated risks for co-morbidities of obesity. The overall impact of this report is high because of the potential utility of the new signatures just discovered and validated, which could assist clinical decision making with more personalized information," explained corresponding author Gerald V. Denis, PhD, associate professor of pharmacology and medicine at BUSM.

These findings appear in the journal PLOS ONE.

Source: Eurekalert
Font : A-A+

Advertisement

Advertisement
Advertisement

Recommended Readings

Latest Research News

Intricate Dance of Flaxseed, Gut Microbiome, and Breast Cancer Genes
Role of flaxseed in the relationship between gut microorganisms and mammary gland microRNAs has been uncovered by a new study.
MRNA Therapy's Promise for Chronic and Acute Liver Disease
New mRNA stem cell therapy, akin to COVID-19 vaccine tech, shows potential against chronic and acute liver diseases.
Could Light Therapy Be a Breakthrough for Alzheimer's?
Light therapy enhances sleep and psycho-behavioral symptoms in Alzheimer's patients with minimal side effects.
Does Twice Daily Stimulation Enhance Alzheimer's Mental Functions?
Electrical stimulation improves Alzheimer's patients' cognitive function and correlates with restored cortical plasticity.
South Korea's 2050 Forecast: Negative Growth Amid Low Fertility
South Korea's total fertility rate, averaging the number of children a woman aged 15-49 has in her lifetime, dropped to 0.81.
View All
This site uses cookies to deliver our services.By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use  Ok, Got it. Close
×

Insight into Blood Signatures of Inflammation Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests