Improving Cancer Survival by Treating Muscle Wasting

Continued treatment of muscle wasting with a soluble growth factor receptor protein improved survival in a pre-clinical cancer model without affecting the tumour size, according to a new study from the University of Jyväskylä in Finland. This effect was not found when the mice were treated with the recombinant protein only prophylactically before cancer.

"These findings, together with a few earlier rodent studies as well as a rather large body of epidemiological evidence in humans, have led to suggestions of a possible causal link between the preservation of muscle mass and improved survival. It can be speculated that the preservation of some specific, vital muscles, such as the major respiratory muscles, may be especially important for this effect," says PhD student Tuuli Nissinen and the Academy of Finland Research Fellow and group leader Juha Hulmi.

Potential Drug Targets for Cancer Uncovered
Several new potential targets using state-of-the-art technology, many of which could be employed for future treatment of different types of cancers and diseases.

‘Treatment of muscle wasting with a soluble growth factor receptor protein improved survival in a pre-clinical cancer model without affecting the tumour size.’

Tweet it Now

"However," they continue, "our results cannot rule out some muscle-independent effects of our protein. It seems that circulating proinflammatory cytokines, physical activity, or hepatic and splenic physiology, which were all altered in cancer, may not be determining factors for improved survival with the soluble growth factor receptor, more specifically soluble activin receptor 2B."

The study was conducted in the Faculty of Sport and Health Sciences at the University of Jyväskylä in collaboration with researchers in Helsinki and Torino.

The results are published in the leading muscle research journal Journal of Cachexia, Sarcopenia and Muscle. The study was funded by the Academy of Finland, the Cancer Society of Finland, and the Jenny and Antti Wihuri Foundation.

New Approach for Treating Lung Cancer Discovered
Special mechanism that regulates tumour growth in lung cancer discovered.

Source-Eurekalert

Computational Method Paves Way for More Personalized Cancer Treatment
New computational strategy has been designed by scientists for more personalized cancer treatment.

New Cancer Research Model Could Accelerate Studies and Reduce Cost
New cancer research model allows researchers to arrive at findings more quickly, to conduct multiple clinical trials of pharmaceutical company drugs across several cancer types, to lessen expenses.