The FDA has issued an alert to healthcare
professionals regarding the use of two cardiac drugs, amiodarone and adenosine,
in prefilled needleless glass syringes.
follows an increasing number of reports of clogging and malfunctions during the
intravenous administration of these drugs using the glass syringes following
incompatibility between the syringe and the access line.
It has been observed that if the syringe and the
access system are incompatible, the pin in the pin-activated IV access system
can break off and block the syringe. This prevents the drug from being released
into the IV line and results in a delay in administration of the drug. At
times, the syringe damages the IV access system or the IV tube, necessitating a
change in the access line. This could also further increase the time taken to
deliver the medication. This delay is unacceptable for drugs like adenosine and
amiodarone, which are used in life-threatening conditions like cardiac
arrhythmias and have to be administered immediately during an emergency.
The FDA advises healthcare professionals to read the
labels of the prefilled syringes carefully to make sure that they are
compatible with the access system being used in the patient. It advises them to
avoid using the prefilled glass syringes in emergencies.
The FDA also advises healthcare professionals to
stock up enough vials or prefilled plastic syringes of these two drugs so that
they can be used in lieu of the prefilled glass syringes in case of a