About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Low Levels of Vitamin D Contribute to Relapse of Ulcerative Colitis

Font : A-A+

Highlights
  • Ulcerative colitis (UC), has been associated with lower levels of vitamin D.
  • New study states that lower levels of vitamin D during disease remission can lead to relapse of UC.
  • Serum levels of vitamin D of 35 ng/mL or less during periods of clinical remission increase the risk of UC relapse.

Low Levels of Vitamin D Contribute to Relapse of Ulcerative Colitis

Lower levels of vitamin D in the blood increase the risk of clinical relapse in patients with Ulcerative Colitis (UC).

The study led by researchers at Beth Israel Deaconess Medical Center (BIDMC) was published in the journal Clinical Gastroenterology and Hepatology.

Advertisement


UC is a chronic inflammatory bowel disease of the large intestine/colon that causes inflammation and ulcers in the lining of the colon.

Ulcerative colitis is the result of an abnormal response by the body's immune system.

In people with IBD immune system mistakes the materials in the intestine for foreign, invading substances and sends white blood cells to fight them resulting in chronic inflammation and ulcerations.
Advertisement

As many as 907,000 Americans may get affected by ulcerative colitis. Both men and women are equally likely to be affected, and most people are diagnosed in their mid-30s.

Patients with active disease have had lower vitamin D levels, but it has been unknown whether they increase disease relapses.

"Prior studies in patients with Crohn's disease and Ulcerative Colitis had linked low vitamin D levels to disease flare-ups," said senior author Alan Moss, MD, a gastroenterologist at the Digestive Disease Center at BIDMC and Associate Professor of Medicine at Harvard Medical School.

"However, it has been unclear if the flare-up was lowering vitamin D levels, or if low vitamin D levels were causing the flare-up. We thought that if we looked at vitamin D levels when the disease was inactive and then followed patients moving forward, the impact of baseline vitamin D levels on future events may be clearer." Moss added.

Study

Researchers conducted a physician-blinded prospective study of 70 patients who were in clinical remission.

Their blood samples were collected to measure serum vitamin D levels and extent of inflammation was assessed through blood tests and biopsies.

After following the patients for 12 months, researchers compared the data from participating patients who remained well and the others who experienced relapses.

The investigators found that in patients who experienced relapse, the mean baseline vitamin D levels were lower.

"Patients who had higher vitamin D levels when their disease was in remission were less likely to experience a relapse in the future," said John Gubatan, MD, a physician at BIDMC and first author of the study.

"This suggests that higher vitamin D levels may play some role in preventing the UC relapse." Gubatan added.

The researchers found that levels of blood vitamin D, greater than 35ng/ml offered a protective role and that was within the range recommended by the National Institutes of Health for a healthy individual.

Researchers are now examining the link between vitamin D and a protein called cathelicidin in the cells lining the colon.

The link may have beneficial effects on microbial composition, an important component of a healthy colon.

Investigators are trying to identify how vitamin D may protect cells in the colon.

References

  1. What is Ulcerative Colitis? - (http://www.ccfa.org/what-are-crohns-and-colitis/what-is-ulcerative-colitis/?referrer=https://www.google.co.in/)
  2. John Gubatan et al. Low Serum Vitamin D During Remission Increases Risk of Clinical Relapse in Patients With Ulcerative Colitis. Clinical Gastroenterology and Hepatology; (2017) doi.org/10.1016/j.cgh.2016.05.035


Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Goji Berries May Protect Against Age-Related Vision Loss
Tapping — A Proven Self-Applied Stress Intervention
Black Pepper as Preventive Measure Against Omicron
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Calcium and Vitamin Supplements Rickets Vitamin Supplements Vitamin C / Ascorbic acid Vitamin B6 Vitamin B9 Vitamin B-12 Vitamin-F Ulcerative Colitis Dandy Walker Syndrome 

Recommended Reading
Digestive Tract Ulcers Symptom Evaluation
A break in the mucus membrane lining of the digestive tract results in ulcers....
Special Diet Helps Children With Crohn’s Disease and Ulcerative Colitis
Specific carbohydrate diet is a nutritionally balanced diet that removes grains, dairy, processed ....
Inadequate Monitoring and Treatment of Anemia Among Patients With Ulcerative Colitis
Testing for iron deficiency anemia was less likely for patients in the Midwest and South regions, .....
Gut Microbiome in Synchrony With Symptoms of Inflammatory Bowel Disease
The gut microbiome of people with inflammatory bowel disease differs from that of healthy patients ....
Calcium and Vitamin Supplements
Calcium and vitamin supplements are taken to provide the body with the ''required'' nutrients. Calci...
Dandy Walker Syndrome
Dandy-Walker syndrome is a brain malformation with symptoms of increased intracranial pressure like ...
Rickets
Encyclopedia section of medindia explains in brief about Rickets...
Ulcerative Colitis
Ulcerative colitis is characterized by bouts of diarrhea, bleeding per rectum and pain, which remits...
Vitamin B-12
Vitamin B-12 is also known as cobalamine or cyanocobalamine, owing to the presence of the metal, cob...
Vitamin B6
Vitamins play an equally important part in the synthesis of neurotransmitters. Neurotransmitters in ...
Vitamin B9
Vital info about vitamin B9, its molecular structure, dietary sources, beneficial aspects, symptoms ...
Vitamin C / Ascorbic acid
Vital info about vitamin C, its molecular structure, dietary sources, beneficial aspects, symptoms o...
Vitamin Supplements
Easy to understand info & tips with diagrams about vitamin supplements like vitamin C, B6, B9 & B12....
Vitamin-F
Essential fatty acids - omega 3 and omega 6 are sometimes referred to as Vitamin F. The body is not...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2022

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE
I have read and I do accept terms of use - Telemedicine

Advantage Medindia: FREE subscription for 'Personalised Health & Wellness website with consultation' (Value Rs.300/-)