About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Diabetes Drug may Help People With Obesity Lose Weight

Font : A-A+

Highlights:
  • A compound in diabetes drug may result in weight loss.
  • But this effect is seen only in people with obesity and not diabetes.
  • This compound is semaglutide, a compound for glycemic control.

Diabetes Drug may Help People With Obesity Lose Weight

Glycemic control drug for weight loss
Semaglutide may help people with obesity. The compound, semaglutide, has a chemical structure that is very similar to the hormone glucagon-like peptide 1 (GLP-1), which regulates both insulin secretion and appetite. In December, the U.S. Food and Drug Administration approved the semaglutide injection Ozempic as a once-weekly adjunct to diet and exercise to improve glycemic control in adults with type-2 diabetes.

"This randomized study of weight loss induced with semaglutide in people with obesity but without diabetes has shown the highest weight reductions yet seen for any pharmaceutical intervention," said lead author Patrick M. O'Neil, Ph.D., Director of the Weight Management Center and Professor of Psychiatry and Behavioral Sciences at the Medical University of South Carolina in Charleston, S.C.

Advertisement


Obesity and not diabetes
The new study included 957 participants, 35 percent of whom were male. All participants had a body mass index (BMI) of at least 30, but did not have diabetes. They were randomly assigned to seven different groups. Five groups received different doses of semaglutide (between 0.05 mg and 0.4 mg) via injection once daily; a sixth group received a placebo, and a seventh group received 3 mg of the diabetes drug liraglutide. All participants received monthly diet and exercise counseling.

After one year, all participants receiving semaglutide had lost significantly more weight than those receiving placebo. The higher the dose participants received, the greater their average weight loss. Participants who received 0.05 mg of semaglutide daily lost an average of 6.0 percent of their body weight; the 0.1 mg group lost an average of 8.6 percent; the 0.3 mg group lost an average of 11.2 percent; and those receiving a daily dose of 0.4 mg lost an average of 13.8 percent. Those receiving liraglutide lost an average of 7.8 percent of their body weight, while those in the placebo group lost only 2.3 percent on average.
Advertisement

Sixty five percent of participants who received 0.4 mg of semaglutide per day lost at least 10 percent of their body weight, compared with 10 percent of those in the placebo group and 34 percent of the liraglutide group.

The most common adverse events in those taking semaglutide were mild/moderate nausea, as seen previously with GLP-1 receptor agonists.

O'Neil noted that further studies of semaglutide for obesity are underway.

References :
  1. ENDO 2018: The Endocrine Society's 100th Annual Meeting & Expo - ( https://www.endocrine.org/)


  2. Source: Eurekalert

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
Quiz on Low-Calorie Diet for Diabetes
World Heart Day in 2022- Use Heart for Every Heart
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Bariatric Surgery Diabetic Retinopathy Drug Toxicity Obesity The Cabbage Diet Diabetes Diabetic Diet Zone Diet Mediterranean Diet Diabetes - Essentials 

Most Popular on Medindia

Color Blindness Calculator How to Reduce School Bag Weight - Simple Tips Hearing Loss Calculator Find a Hospital Daily Calorie Requirements Pregnancy Confirmation Calculator Noscaphene (Noscapine) Indian Medical Journals Blood Donation - Recipients Post-Nasal Drip
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Diabetes Drug may Help People With Obesity Lose Weight Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests