About Careers Internship MedBlog Contact us

Bladder Cancer Biomarker Fails to Explain Treatment Strategies

Font : A-A+

  • Bladder Cancer is the fourth most common cancer among men.
  • Neutrophil to lymphocyte ratio (NLR) biomarker is useful in detecting the progress of bladder cancer.
  • A new study from Penn Medicine finds NLR biomarker to be ineffective in determining treatment options for bladder cancer.

Bladder Cancer Biomarker Fails to Explain Treatment Strategies

A new research study from the University of Pennsylvania School of Medicine found promising biomarker( neutrophil to lymphocyte ratio) in detecting cancer progress to be clueless or not reliable for determining the effective treatment options.

The research study was published in the journal Cancer this week.


Previous studies related to bladder cancer biomarker called neutrophil to lymphocyte ratio(NLR)was found to detect the worsening of overall survival rate after bladder cancer surgery (radial cystectomy). The blood test will also be capable of predicting the patients who will be benefit from presurgery chemotherapy.

The present research study led by Eric Ojerholm MD, Department of Radiation Oncology in the Perelman School of Medicine at the University of Pennysylvania raised certain doubts to the previous studies which focused NLR to be effective in determining the survival rate for bladder cancer. They also found that NLR was not helpful in predicting the chemotherapy benefits before surgery.

Ojerholm said, "Dozens of earlier studies reported NLR as a biomarker for bladder cancer, and we hoped that this would be true."

"Yet extraordinary claims require extraordinary evidence. And all prior studies relied on observational datasets. Many also used statistical methods that can lead to false positive results. So we decided to rigorously put NLR to the test." he added.

The research team analyzed data collected from the SWOG 8710 clinical trial with 317 bladder cancer patients who had radial cystectomies. Out of which half of these patients had chemotherapy treatment prior to surgery.

"First, baseline blood samples were collected as part of the trial protocol. Second, the study's long-term follow-up gave us adequate 'statistical power,' meaning that if NLR really was a biomarker, then we should be able to detect it. Third, the trial randomly assigned some patients to receive pre-surgery chemotherapy. This allowed us to test NLR both as a prognostic and predictive biomarker." Ojerholm said.

The research team identified 230 patients for prognostic analysis and 263 patients for predictive analysis to determine the overall survival rate and chemotherapy benefits for bladder cancer respectively.

The study findings found both the analysis to have no significant results. And the author states it could be a problem of publication bias as authors fail to present negative results and sometimes journal also fails to accept them.

The author concludes that no single study could be definitive and more evidence and research is required before using this biomarker.

Source: Medindia

Citations   close

Please use one of the following formats to cite this article in your essay, paper or report:

  • APA

    Madhumathi Palaniappan. (2016, October 27). Bladder Cancer Biomarker Fails to Explain Treatment Strategies. Medindia. Retrieved on Sep 26, 2022 from https://www.medindia.net/news/healthwatch/bladder-cancer-biomarker-fails-to-explain-treatment-strategies-164685-1.htm.

  • MLA

    Madhumathi Palaniappan. "Bladder Cancer Biomarker Fails to Explain Treatment Strategies". Medindia. Sep 26, 2022. <https://www.medindia.net/news/healthwatch/bladder-cancer-biomarker-fails-to-explain-treatment-strategies-164685-1.htm>.

  • Chicago

    Madhumathi Palaniappan. "Bladder Cancer Biomarker Fails to Explain Treatment Strategies". Medindia. https://www.medindia.net/news/healthwatch/bladder-cancer-biomarker-fails-to-explain-treatment-strategies-164685-1.htm. (accessed Sep 26, 2022).

  • Harvard

    Madhumathi Palaniappan. 2021. Bladder Cancer Biomarker Fails to Explain Treatment Strategies. Medindia, viewed Sep 26, 2022, https://www.medindia.net/news/healthwatch/bladder-cancer-biomarker-fails-to-explain-treatment-strategies-164685-1.htm.


News A-Z
What's New on Medindia
H1N1 Influenza Prevention in Children: What Parents Need to Know
Dietary Factors Responsible for Dihydrotestosterone (DHT) Production and Hair Loss
Test Your Knowledge About Chromosomes?
View all
Recommended Reading
News Archive
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Cancer and Homeopathy Vesico-Ureteric Reflux Causing UTI in Children Enuresis/Bedwetting Cancer Facts Cancer Tattoos A Body Art Interstitial Cystitis Bladder Cancer Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

Most Popular on Medindia

Loram (2 mg) (Lorazepam) Hearing Loss Calculator Selfie Addiction Calculator Find a Doctor Diaphragmatic Hernia Sanatogen How to Reduce School Bag Weight - Simple Tips Sinopril (2mg) (Lacidipine) Blood Pressure Calculator Drug - Food Interactions
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use

Bladder Cancer Biomarker Fails to Explain Treatment Strategies Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests