About Careers MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

Antibiotic Combination Therapy Helps Target Superbugs

Font : A-A+

Highlights
  • The drug-resistant bacteria causes infection by inactivating penicillin antibiotics using enzymes called beta-lactamases and in particular the metallo-beta-lactamases (MBLs).
  • The new combination therapy uses two antibiotic drugs to protect each other from being rendered inactive by the problematic bacterial enzymes.
  • The antibiotics interferes with the other’s activity to fight infections.

Antibiotic Combination Therapy Helps Target Superbugs

Penicillin-resistant bacteria causes infection by using enzymes known as beta-lactamases to chop up the antibiotics rendering them useless.

There is a particular group of bacterial beta-lactamases known as metallo-beta-lactamases (MBLs), that is able to destroy even the newest penicillins.

Advertisement


MBLs are often made by bacteria in conjunction with other enzymes, including other beta-lactamases that allow certain bacteria to destroy the entire penicillin arsenal.

Antibiotic-resistant infections can be defeated by combining two different antibiotics that each block a different kind of drug-destroying enzyme secreted by bacteria, have been discovered by researchers in Cleveland Ohio.
Advertisement

When combined, the antibiotics interferes with the other's activity to fight infections.

This equips the doctors with a new weapon to overcome one of the most pernicious infections caused by deadly bacteria endemic to hospitals.

Combination Therapy

According to a multicenter epidemiologic study, carbapenem-resistant enterobacteriaceae (CRE), causes approximately one-third of healthcare-associated infections in the United States and kills nearly half its victims

The new findings state that the novel combination antibiotic drug regimen proved effective against 81% of CRE specimens tested.

The study was conducted under the leadership of Robert A. Bonomo, MD, Professor of Medicine, Pharmacology, Biochemistry, Molecular Biology, and Microbiology at Case Western Reserve University School of Medicine and Chief of Medical Service at the Louis Stokes Cleveland Veterans Affairs Medical Center.

The strategy uses two antibiotic drugs to protect each other from being neutralized by CRE's problematic enzymes.

An antibiotic combination regimen of ceftazidime/avibactam is used in the first combination strategy and these are vulnerable to the neutralizing effect of the metallo-beta-lactamases.

The next half uses aztreonam, which is not vulnerable to the neutralizing effect of the metallo-beta-lactamases but is vulnerable to other types of CRE enzymes, which are in turn neutralized by ceftazidime/avibactam.

When used in combination, the two antibiotics run interference for each other and in tag-team fashion defeat the infection.

The novel combination helps doctors overcome the antibiotic neutralizing metallo-beta-lactamases.

As the other half of the regimen offers protection, "aztreonam skirts around the metallo-beta-lactamase and hits its target--the penicillin-binding proteins," Bonomo explained in a Center for Infectious Disease Research and Policy feature.

Aztreonam attaches to their penicillin-binding proteins of the bacteria, and prevents it from building effective cell walls with the drug in the way, and this causes them to die quickly.

Bonomo said, "If we understand the fundamental mechanisms by which bacteria become resistant to antibiotics, we can use what we know to help design better therapies."

The combination approach still needs to go through clinical trials and undergo additional research before it can become a commonly used treatment. It is however extremely promising news for doctors worldwide low on options to treat patients with antibiotic-resistant infections.

The findings are published in Antimicrobial Agents and Chemotherapy.

Reference

  1. Robert A. Bonomo et al. Bacteremia due to Carbapenem-resistant Enterobacteriaceae (CRE): A Multicenter Clinical and Molecular Epidemiologic Analysis in the Nation's Epicenter for CRE. Antimicrobial Agents and Chemotherapy; (2017) doi: 10.1128/AAC.02349-16


Source: Medindia

Citations   close

Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Test  Your Knowledge on Heart
Test Your Knowlege on Genes
Obesity in Teens Make Inroads into Early Atrial Fibrillation
View all
Recommended Reading
News Archive
Date
Category
Advertisement
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Reiki and Pranic Healing MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Combination Therapy for High Blood Pressure Antibiotics Eye Infections Natural Antibiotics to Fight Bacterial Infections Vancomycin-Resistant Enterococci (VRE) Boils - Treatment by Drugs Multiple Drug Allergy Syndrome 

Most Popular on Medindia

Color Blindness Calculator Calculate Ideal Weight for Infants Sinopril (2mg) (Lacidipine) Blood - Sugar Chart Selfie Addiction Calculator A-Z Drug Brands in India The Essence of Yoga Noscaphene (Noscapine) Drug Side Effects Calculator Pregnancy Confirmation Calculator
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
×

Antibiotic Combination Therapy Helps Target Superbugs Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests