- A new molecule called peptidoglycan has been identified in Lyme arthritis patients
- Peptidoglycan was present in the synovial fluid of affected joints of patients
- This could lead to the development of better diagnostics and treatments for Lyme disease
Lyme arthritis is a very painful and highly debilitating condition. The study findings indicate that when the causative bacterium Borrelia burgdorferi multiplies in the body, it releases a cellular component known as peptidoglycan that can produce severe inflammatory reactions.
Facts about Lyme Disease
- Lyme disease is caused by the bacterium B. burgdorferi and transmitted by infected ticks
- Lyme disease is the highest reported vector-borne disease in the US
- Lyme disease incidence has increased over 6,000 percent in the past 15 years in Virginia, USA
- 300,000 people are diagnosed with Lyme disease annually in the US
- Climate change will increase the prevalence of Lyme disease
The study, which has been published in the Proceedings of the National Academy of Sciences of the United States of America (PNAS), is the fruit of four years of painstaking research that began when Jutras was a postdoctoral fellow in the lab of Dr. Christine Jacobs-Wagner, PhD, who is a Professor in the Department of Microbial Pathogenesis at Yale School of Medicine, New Haven, Connecticut, USA.
- Clinical samples were obtained from confirmed Lyme disease patients
- Patients were refractory to oral and/or intravenous antibiotics
- Peptidoglycan was present in the synovial fluids of the patients
- Peptidoglycan was purified from other bacterial components
- Mouse model was used to test if arthritis could be induced by peptidoglycan alone
- Peptidoglycan is responsible for Lyme arthritis in late-stage Lyme disease
- Peptidoglycan was detected in the synovial fluid of affected joints in patients with Lyme arthritis, who did not have any active infection
- In the mouse model, injection of purified peptidoglycan caused severe joint inflammation within 24 hours, proving that peptidoglycan can cause arthritis
- This rapid inflammatory reaction could arise from the unique molecular structure of peptidoglycan in the bacterium B. burgdorferi
Implications of the StudyThe study findings will help to develop better techniques to diagnose Lyme disease and Lyme arthritis in patients with non-specific symptoms, by detecting peptidoglycan in synovial fluid.
Future PlansExperiments are being planned to better understand the chemical structure of peptidoglycan, which will help to elucidate how the molecule persists in the body and produces other manifestations of Lyme disease. This will be followed by developing therapeutic strategies to target and destroy the peptidoglycan molecule. This will resolve the symptoms and help in the recovery of patients with Lyme disease.
Concluding RemarksJutras concludes: "This discovery will help researchers improve diagnostic tests and may lead to new treatment options for patients suffering from Lyme arthritis." He adds: "This is an important finding, and we think that it has major implications for many manifestations of Lyme disease, not just Lyme arthritis."
- Borrelia burgdorferi peptidoglycan is a persistent antigen in patients with Lyme arthritisá - (https://www.pnas.org/content/early/2019/06/11/1904170116)
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