Four Hallmarks of Cancer Metastasis Discovered

by Colleen Fleiss on  May 6, 2019 at 9:55 AM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

Four hallmarks of metastasis namely motility and invasion, modulation of the microenvironment, plasticity and ability to colonize have been discovered by researchers at the University of Alabama at Birmingham and the University of Kansas Cancer Center. Metastasis is believed to be the cause of up to 90 percent of cancer deaths.
Four Hallmarks of Cancer Metastasis Discovered
Four Hallmarks of Cancer Metastasis Discovered

Douglas Hurst, Ph.D., assistant professor in the UAB Department of Pathology, and Danny Welch, Ph.D., associate director of Education at the KUCC, conducted a literature review of more than 10,000 publications on metastasis, and published their findings in Cancer Research, from the American Association for Cancer Research.

Metastasis can be very difficult to treat. Virtually any cancer type can form metastatic tumors. The most common sites for cancers to metastasize include the brain, bones, lungs and liver. Other areas include the adrenal gland, lymph nodes, skin and other organs.

By defining the unique properties of metastatic cancer cells, Hurst says, he hopes to provide a conceptual framework to accelerate the discovery of treatment strategies.

"Our attempts to identify the underlying first principles of the metastatic process hopefully provide a means for simplifying the processes that are essential for all metastases to develop," the authors said in the review.

Hurst and Welch identified four hallmarks of metastasis:

Motility and invasion

Modulation of the microenvironment

Plasticity

Ability to colonize

Defining the hallmarks of metastasis has been complicated by both heterogeneity among tumor cells, and the myriad interactions with other molecules and cells throughout the process, according to the authors.

Hurst and Welch say they hope that refining definitions and bringing together diverse data will identify vulnerabilities that metastasis researchers can exploit in the quest to treat cancer metastasis.

Hurst, who also serves as an associate scientist at the O'Neal Comprehensive Cancer Center at UAB, explains why metastasis is hard to understand.

Source: Eurekalert

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions
Advertisement

More News on:

Cancer and Homeopathy Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive