As for why the magazine chose the South African beauty, well that's not only because of her stunning looks, but also her stellar career.
She won an Oscar for "Monster".
And she's not only ready to take a dig at herself, but also at politicians such has US President George Bush, reports the New York Daily News.
Theron recently said: "I grew up in a country that learned the lesson that you can't impose your way of life on 26 different kinds of people just because you call yourself righteous. I think there are lessons this country still has to learn."