Enzymes That Block Telomerase Show Promise in Cancer Therapy

by Anjali Aryamvally on  May 17, 2018 at 12:59 PM Cancer News
RSS Email Print This Page Comment bookmark
Font : A-A+

New study has discovered two antioxidant enzymes that work together to prevent oxidation of telomeric DNA at chromosome ends. The study led by Joachim Lingner and Wareed Ahmed at EPFL found that disrupting both the enzymes, called PRDX1 and MTH1, in cancer cells, shrunk the cells' telomeres with every round of cell division, eventually disappearing altogether.
Enzymes That Block Telomerase Show Promise in Cancer Therapy
Enzymes That Block Telomerase Show Promise in Cancer Therapy

Before cell division, the long strings of the cell's DNA are wrapped tightly into the structures we know as chromosomes. This protects the cell's genetic material from physical and chemical damage.

The ends of chromosomes are called telomeres . These are specialized structures that have to be replicated with each cell division cycle. But the complete replication of telomeres up to the very ends of chromosomes also requires specialized mechanisms, and these are limited. Telomeres are also very sensitive to oxidative damage, which affects their ability to replicate.

Because of this, telomeres shrink over time, limiting the lifespan of cells. Telomere shortening is essentially the cause of cell aging.

One of the promising targets in cancer therapy is the enzyme telomerase. Normally, telomerase prevents telomeres from shortening in germ and stem cells, which helps with development. But telomerase is also highly active in cancer cells, keeping their telomeres intact and making the cells virtually immortal. The new work shows that disrupting PRDX1 and MTH1 prevents telomerase from counteracting telomere shortening.

So far, attempts to efficiently block telomerase in cancer have not been fruitful in the clinic. The discovery of the co-operating enzymes opens up a new opportunity to indirectly block telomerase. "Instead of inhibiting the enzyme itself, we target its substrate - the chromosome end - making it un-extendable by telomerase," says Lingner.



Source: Eurekalert
Advertisement

Post a Comment

Comments should be on the topic and should not be abusive. The editorial team reserves the right to review and moderate the comments posted on the site.
Notify me when reply is posted
I agree to the terms and conditions

More News on:

Cancer and Homeopathy Anti-ageing and Benefits of Red Wine Reiki and Pranic Healing Cancer Facts Cancer Tattoos A Body Art Common Lifestyle Habits that Cause Diseases Health Benefits of Dandelion Plant 

News A - Z

A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

News Search

Medindia Newsletters

Subscribe to our Free Newsletters!

Terms & Conditions and Privacy Policy.

Find a Doctor

Stay Connected

  • Available on the Android Market
  • Available on the App Store

News Category

News Archive

Loading...