A potential cure for a rare eye disease has been developed by University of British Columbia and Vancouver Coastal Health scientists. They have shown for the first time that a drug can repair a birth defect.
They formulated the drug Ataluren into eye drops, and found that it consistently restored normal vision in mice who had aniridia (ANN-uh-ridee-uh), a condition that severely limits the vision of about 5,000 people in North America. A small clinical trial with children and teens is expected to begin next year in Vancouver, the U.S. and the U.K.
Amblyopia
Amblyopia is the loss of one eye''s ability to see details. Amblyopia is otherwise known as lazy eye.
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Aniridia is caused by the presence of a "nonsense mutation" - an extra "stop sign" on the gene that interrupts production of a protein crucial for eye development. Aniridia patients don't have an iris (the coloured ring around the pupil), and suffer many other eye abnormalities.
Ataluren is believed to have the power to override the extra stop sign, thus allowing the protein to be made. The UBC-VCH scientists initially thought the drug would work only in utero - giving it to a pregnant mother to prevent aniridia from ever arising in her fetus. But then they gave their specially formulated Ataluren eye drops, which they call START, to two-week-old mice with aniridia, and found that it actually reversed the damage they had been born with.
Source: Eurekalert
Source: Eurekalert
Conjunctivitis
Conjunctivitis or Pink Eye causes redness and soreness of the conjunctiva and is responsible for 1% of all emergency visits to a hospital.
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Dry Eye Symptom Evaluation
Dry eye may be due to a decrease in tear production, alteration of the tear consistency, or faster evaporation of the tears.
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