Researchers say that if doctors underplay the pain of a procedure, patients might avoid the nocebo effect - the placebo effect's evil twin. By downplaying the level of pain that comes with a surgical procedure, patients could actually feel a lot less pain.
Arne May's team at the University of Hamburg, Germany, applied heat to the arms of 38 volunteers over six days.
Half of them were told the heat would get more intense, and they reported constant pain levels.
The first group also had increased activity in a brain area involved in pain perception.
"I didn't expect that giving negative information for 5 minutes would have an effect a week later," New Scientist quoted May as saying.
The study has been published in the Journal of Neuroscience.