Down Syndrome Children Have Less Survival Chance in Leukemia

Children with Down syndrome have a lower chance of survival from a particularly high-risk form of leukemia (ALL) than children without the disability, shows new research.

Generally, Down syndrome children have a higher risk of developing acute lymphoblastic leukemia (ALL) than children without this disability. But the effect of cancer treatment is still unknown.

Down Syndrome - Trisomy 21, Causes, Symptoms, Diagnosis, Treatment, Prognosis
Down Syndrome is a congenital disorder among children commonly born to older mothers. The condition is also known as ‘Up syndrome’ because of the cheerful persona of the Down children.

‘Children with Down syndrome need cancer treatments with fewer side effects.’

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In a new study published in the journal The Lancet Haematology, scientists compared the effect of therapy in leukemia patients with and without Down syndrome.

To account for differences in known risk factors, data from 136 leukemia patients with Down syndrome were matched with those from 407 children who did not have Down syndrome.

Their analysis showed that the levels of leukemia cells decreased equally well in both groups of children after the first month of treatment.

Acute Lymphoblastic Leukemia - Incidence Causes Symptoms Diagnosis Treatment Prognosis
Acute lymphoblastic leukemia (ALL) is the cancer of white blood cells characterized by excess lymphoblasts. It is the most common of all childhood cancers and can be fatal in weeks if left untreated.

The long-term outcome of children with and without Down syndrome differed. Children with Down syndrome had a worse outcome than children without the disability.

Children with Down syndrome also were more likely to see their leukemia return within five years of treatment. Researchers believe this difference is due to interaction between the genetic changes in Down syndrome.

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Neutropenic sepsis is a potentially life-threatening condition when a patient with low neutrophil counts develops an infection that spirals out of control if not treated urgently and is usually seen in cancer patients on chemotherapy.

Continuing research for treatments with fewer side effects such as targeted therapies and forms of immunotherapy can provide better treatment for children with Down syndrome.

Source-Medindia

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