A new study to be presented by Dana-Farber/Children's Hospital Cancer Center at the American Society of Pediatric Hematology Oncology meet in Miami reveals that children from racial and ethnic minority families who do not have private health insurance have to undergo a more invasive and potentially life threatening course of treatment for eye cancer retinoblastoma compared to other children due to delays in diagnosis.
By analyzing data and tumor samples from 203 children across the United States who had been treated for retinoblastoma, the investigators found that the disease was more invasive at diagnosis in patients who were non-white, Hispanic, uninsured, or covered by Medicaid. Researchers now need to explore why the disease tends to be diagnosed later in such children and how those delays can be eliminated, said the study authors.
Amblyopia
Amblyopia is the loss of one eye''s ability to see details. Amblyopia is otherwise known as lazy eye.
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Retinoblastomas are tumors that develop during childhood in the light-sensitive retina at the back of the eye. There are about 350 new cases diagnosed each year in the United States. Treatment may require surgical removal of the affected eye and, if the disease is likely to spread, follow-up chemotherapy.
"The longer that retinoblastomas grow before they're diagnosed and treated, the more invasive they become," said the study's lead author, Adam Green, MD, of DF/CHCC. "In this study, we used tumor invasiveness as an indicator of delays in disease diagnosis."
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Data and tumor tissue used in the study came from pediatric retinoblastoma patients participating in a clinical trial run by the Children's Oncology Group, a consortium of more than 8,000 childhood cancer experts on three continents. All the patients had the diseased eye surgically removed, and those whose disease was deemed likely to spread received chemotherapy.
Investigators collected data on patients' insurance status, race, and ethnicity. The tumor tissue samples were examined by pathologists for signs that the tumors would metastasize.
"We correlated the demographic data with the results of the pathology exams to see if children with retinoblastoma who were non-white, Hispanic, or who did not have private health insurance were more likely to have disease invasiveness at diagnosis requiring chemotherapy in addition to surgery, a stage of disease that may carry a lower survival rate," Green said. "The answer was yes."
Of the factors most associated with invasive disease, Hispanic ethnicity had the greatest impact on risk, researchers found, raising the possibility that not speaking English as one's primary language poses a particular barrier to timely diagnosis and treatment.
"We now need to find out where in the diagnostic process the delays are occurring," said the senior author of the study, Carlos Rodriguez-Galindo, MD, of DF/CHCC. "Is it because patients' families aren't familiar with the warning signs of the disease, because they have trouble getting to a primary care doctor or ophthalmologist for an exam, or some other factor? We hope to explore those questions in future studies."
Source: Eurekalert
Clear the Blur-Tips to Boost Your Eye-Q
Eye problems may present as blurry vision or simply a minor headache, but they can affect your life in more ways than one. Here's a comprehensive yet compact guide to boost your eye-Q.
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Data and tumor tissue used in the study came from pediatric retinoblastoma patients participating in a clinical trial run by the Children's Oncology Group, a consortium of more than 8,000 childhood cancer experts on three continents. All the patients had the diseased eye surgically removed, and those whose disease was deemed likely to spread received chemotherapy.
Investigators collected data on patients' insurance status, race, and ethnicity. The tumor tissue samples were examined by pathologists for signs that the tumors would metastasize.
"We correlated the demographic data with the results of the pathology exams to see if children with retinoblastoma who were non-white, Hispanic, or who did not have private health insurance were more likely to have disease invasiveness at diagnosis requiring chemotherapy in addition to surgery, a stage of disease that may carry a lower survival rate," Green said. "The answer was yes."
Of the factors most associated with invasive disease, Hispanic ethnicity had the greatest impact on risk, researchers found, raising the possibility that not speaking English as one's primary language poses a particular barrier to timely diagnosis and treatment.
"We now need to find out where in the diagnostic process the delays are occurring," said the senior author of the study, Carlos Rodriguez-Galindo, MD, of DF/CHCC. "Is it because patients' families aren't familiar with the warning signs of the disease, because they have trouble getting to a primary care doctor or ophthalmologist for an exam, or some other factor? We hope to explore those questions in future studies."
Source: Eurekalert
Eye Pain Symptom Evaluation
Eye pain usually follows trauma, eye infection or inflammation of the eye and the surrounding structures. The cause of eye pain can be diagnosed based on the type of pain and associated symptoms.
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