Common Heartburn Medications Pose Risks for Chronic Kidney Disease

Proton-pump inhibitors (PPIs) are commonly prescribed or available as over-the-counter drugs for treating heartburn, indigestion and acid reflux.

Most of us just grab a pill or syrup to get rid of heartburn, indigestion and acid reflux. But these popular medicines may increase the risk of chronic kidney disease, revealed a new study.

The study published in the Journal JAMA Internal Medicine has showed that common drugs called proton-pump inhibitors (PPIs) that treat heartburn and indigestion may pose risks for chronic kidney disease.

Effects Of Common Heartburn Drugs on Chronic Kidney Disease
Researchers found that proton pump inhibitors (PPI) use was linked with a 10 percent increased risk of CKD and a 76 percent increased risk of dying prematurely.

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Proton pump inhibitor use is associated with a higher risk of incident chronic kidney disease.

”People who use proton pump inhibitors (PPIs) have a 20 percent to 50 percent higher risk of chronic kidney disease compared with nonusers,” said lead author Dr. Morgan Grams, an assistant professor of epidemiology at Johns Hopkins University in Baltimore.

PPIs are sold by prescription and over-the-counter under a variety of brand names, including Nexium, Prilosec and Prevacid in the US.

In the study, researchers analyzed the medical records of two groups of people: 10,482 participants in the Artherosclerosis Risk in Communities (ARIC) study and 248,751 patients in the Geisinger Health System in Pennsylvania.

Association Between Common Heartburn Drugs and Risk of Pneumonia Questioned
A true cause-and-effect relationship may not have been found by previous studies that have associated the use of proton pump inhibitors (PPI) with an increased incidence of pneumonia.

In the ARIC study, they found that among 322 people examined the absolute risk for chronic kidney disease was 11.8 percent while the expected risk would have been 8.5 percent.

In the Geisinger Health System, among the 16,900 patients the absolute risk was 15.6 percent, whereas 13.9 percent would have been expected to develop chronic kidney disease.

Heartburn Drugs Cause Osteoporosis in Later Life
Heartburn pills can lead to more than one bargained for - the drugs have been linked to an increased risk of the bone disease osteoporosis.

Grams said, "We found there was an increasing risk associated with an increasing dose. That suggests that perhaps this observed effect is real. But as many as 70 percent of these prescriptions have been handed out inappropriately, and 25 percent of long-term users could stop taking the medication without suffering increased heartburn or acid reflux.”

“No one is sure how the drugs might damage the kidneys, but a couple of leading theories exist. The medications can cause magnesium levels to decline in the body, and a lack of this important mineral could damage the kidneys. The kidneys also might become damaged over time if patients suffer repeated bouts of acute kidney inflammation due to proton pump inhibitors,” Grams added.

Acid Reducing Medications may Increase Risk of C.Diff Infection in Children
Pediatricians may do more harm than good by prescribing acid-reducing drugs for infants with non-specific gastrointestinal symptoms like occasional vomiting.

Reference: Morgan E. Grams, Benjamin Lazarus, “Proton Pump Inhibitor Use and the Risk of Chronic Kidney Disease,” JAMA Intern Med., doi:10.1001/jamainternmed.2015.7193

Source-Medindia