About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Childhood Coxsackie Virus Infection Depletes Cardiac Stem Cells in Adults

by Bidita Debnath on August 3, 2014 at 11:31 PM
Font : A-A+

 Childhood Coxsackie Virus Infection Depletes Cardiac Stem Cells in Adults

There is epidemiological evidence that links heart disease with type B coxsackie virus (CVB) infection.

And research published on July 31st in PLOS Pathogens now suggests a mechanism by which early infection impairs the heart's ability to tolerate stress at later stages of life.

Advertisement

CVB infection is very common and affects mostly children. The symptoms range widely: over half of the infections are thought to be asymptomatic, the majority of children who get sick have only a mild fever, and a very small proportion get inflammation of the heart or brain. On the other hand, 70 - 80% of patients with heart failure show signs of a previous CVB infection but have no history of viral heart disease, raising the possibility that even a mild earlier infection makes them more vulnerable to get heart disease later on.

To investigate this, researchers from San Diego State University, USA, led by Roberta Gottlieb and Ralph Feuer, first established a mouse model of mild juvenile CVB infection. Mice infected with a non-lethal dose of the virus shortly after birth did not develop any heart disease symptoms during the infection or into adulthood, but they had a predisposition to heart disease later in life.
Advertisement

Detailed analysis of the mice after infection showed that the virus does indeed target the heart and is found in cardiac stem cells. When comparing the numbers of cardiac stem cells in previously infected adult mice with uninfected ones, the researchers found significantly smaller numbers in the infected mice.

To test whether the childhood infection and stem cell depletion had any effect on the adult heart, the researchers exposed infected mice to two different types of cardiac stress. They treated some of the mice with a drug known to overstimulate the heart, and they challenged another group by making them swim for 90 minutes every day for 14 days. Following both treatments, the infected mice showed clear signs of early heart disease whereas uninfected controls showed little or no symptoms.

Analyzing the stressed mice in more detail, the researchers found that the hearts from previously infected mice had impaired ability to re-arrange their heart blood vessels and grow new ones. This process, called vascular remodeling, is critical for the heart to respond to changes in the environment, including stress.

As discussed in the article, important open questions remain. For example, does CVB infection affect cardiac stem cells at any age, or is there a vulnerable period in early childhood? It is also not clear whether other strains of CVB have similar properties to the one used here, which was isolated from a patient with heart disease.

Nonetheless, the researchers conclude that their results "support the hypothesis that a mild CVB3 infection early in development can impair the heart's ability to undergo physiologic remodeling, leading to heart disease later in life". They also suggest that "the subtle cardiac alterations might go undetected under normal circumstances but emerge in the setting of increased demand such as intense exercise or chronic high blood pressure".

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
News Category
What's New on Medindia
Printed Temperature Sensors help with Continuous Temperature Monitoring
Health Benefits of Giloy
Breast Cancer Awareness Month 2021 - It's time to RISE
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Chicken Pox Stem Cells - Cord Blood Stem Cells - Fundamentals Shigellosis Parkinsons Disease Surgical Treatment Palpitations And Arrhythmias Genetics and Stem Cells Flu Statins Cardiomyopathy 

Recommended Reading
Cardiac Stem Cells Show Promise
Cardiac stem cells could help improve blood-pumping ability and restore vitality in heart muscle, .....
Molecular Interconnection Discovery Could Help Generate Cardiac Stem Cells
The discovery of a three-way molecular interconnection could help generate cardiac stem cells, it .....
Beware of Claims About Cosmetic Stem Cells Procedures: Review
Advertising claims for cosmetic procedures using stem cells are running far ahead of the scientific ...
Natural Sugar Mimics Guide Stem Cells Toward Neural Fate
Embryonic stem cells can develop into a multitude of cells types and researchers would like to ......
Cardiomyopathy
Cardiomyopathy weakens the heart muscles and the heart loses strength to pump blood throughout the b...
Chicken Pox
Chicken pox is an acute and highly contagious viral infection caused by the varicella zoster virus....
Palpitations And Arrhythmias
Palpitations are unpleasant sensation of one’s own heartbeat....
Shigellosis
Shigellosis or Bacillary Dysentery is a common cause of gastro-enteritis worldwide and can cause blo...
Statins
Statins are new wonder drugs that are proving to be efficacious, not merely in relieving symptoms bu...
Stem Cells - Fundamentals
Encyclopedia section of medindia gives general info about Stem Cells...
Stem Cells - Cord Blood
Encyclopedia section of medindia gives general info about Cord Blood...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use