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Benefits of Dexamethasone may Differ Among COVID-19 Patients

by Karishma Abhishek on November 15, 2020 at 12:41 PM
Benefits of Dexamethasone may Differ Among COVID-19 Patients

Dexamethasone - a steroid used significantly to reduce COVID-19 mortality, may be less effective in patients with diabetes, according to a research at the Advanced Photon Source (APS), a U.S. Department of Energy (DOE) Office of Science User Facility at DOE's Argonne National Laboratory.

A blood protein, called serum albumin binds with dexamethasone and is responsible for transporting them throughout the body. Patients with diabetes may have low levels of serum albumin due to high blood sugar.


This changes the way albumin binds with dexamethasone and hence, reduces the drug efficacy, shows a study published in the Journal of the International Union of Crystallography.

The research team led by scientists at the University of Virginia, used powerful X-rays from the APS to get a full picture of the structure of serum albumin combined with dexamethasone, with aid of remote access technology. These findings re-emphasize the ways, physicians prescribe the drug for certain patients.

"Gaining new insight into the mechanisms of this drug will help doctors design more effective treatments," said Argonne's Bob Fischetti, life sciences advisor to the APS director. "Since the start of this pandemic, the APS has been a powerful tool for gaining insights into the virus itself, and into methods for combating it."

Source: Medindia
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