Over the last years, a new generation of human immunodeficiency virus (HIV) neutralizing antibodies
was identified. These antibodies are highly potent and are able to
effectively neutralize a large number of different HIV strains.
Therefore, they play an important role in the quest for and development
of an HIV vaccine.
A research team led by investigators of the Rockefeller University in
New York and Prof Florian Klein, University Hospital Cologne and German
Center for Infection Research (DZIF), has tested a new HIV neutralizing
antibody, called 10-1074, in humans. The results of the trial have just
been published in Nature Medicine.
AIDS/HIV - Prevention And Transmission
Encyclopedia section of medindia explains in brief about the prevention for AIDS/HIV
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‘A new human immunodeficiency virus (HIV) neutralizing antibody, called 10-1074, when tested in humans was well tolerated and demonstrated favorable pharmacokinetic properties.’
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In close collaboration with the Division of Infectious Diseases at the University Hospital Cologne (Prof Gerd Fätkenheuer) and scientists of the Rockefeller University in New York, Prof Klein's research group is investigating whether broadly neutralizing antibodies can be used to treat HIV infection.
The just published trial investigates this approach. The broadly
neutralizing antibody 10-1074 targets a specific structure (V3 loop) on
the HIV envelope protein. In the study, the investigators show that the
antibody was well tolerated and demonstrated favorable pharmacokinetic
properties.
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The Acquired immune deficiency syndrome is brought about by the deadly human immunodeficiency virus. In the USA alone an estimate of 120,000 - 160,000 women are HIV- infected.
Additionally, the antibody showed high antiviral activity in the participants with HIV infection. Furthermore, the team was able to specifically investigate the development of resistant HIV variants.
"We performed a comprehensive HIV sequence analysis to investigate the dynamics and mechanisms HIV uses to escape the selection pressure by the antibody," says Dr. Henning Gruell, one of the first authors of the current publication.
"This trial was only possible because of the intensive collaboration with the Rockefeller University and many other clinical and scientific partners," says Prof Klein, principal investigator in Germany and co-last author of the study. The scientists are planning further trials to investigate an antibody-mediated treatment approach in patients with HIV infection. Further trials have already been scheduled for spring.
Source: Eurekalert
AIDS and Pregnancy
The Acquired immune deficiency syndrome is brought about by the deadly human immunodeficiency virus. In the USA alone an estimate of 120,000 - 160,000 women are HIV- infected.
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Additionally, the antibody showed high antiviral activity in the participants with HIV infection. Furthermore, the team was able to specifically investigate the development of resistant HIV variants.
"We performed a comprehensive HIV sequence analysis to investigate the dynamics and mechanisms HIV uses to escape the selection pressure by the antibody," says Dr. Henning Gruell, one of the first authors of the current publication.
"This trial was only possible because of the intensive collaboration with the Rockefeller University and many other clinical and scientific partners," says Prof Klein, principal investigator in Germany and co-last author of the study. The scientists are planning further trials to investigate an antibody-mediated treatment approach in patients with HIV infection. Further trials have already been scheduled for spring.
Source: Eurekalert
AIDS/HIV
"AIDS is an epidemic disease, a potentially preventable, deadly infection for which there is no cure, no vaccine, and it is not under control." - National Commission on AIDS, 1993.
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 AIDS/HIV - EpidemiologyAIDS or HIV is an epidemic disease, a potentially deadly infection that can be prevented with precautions. AIDS/HIV symptoms manifest long after the actual infection occurs. | Advertisement
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