About My Health Careers Internship MedBlogs Contact us
Medindia LOGIN REGISTER
Advertisement

Antibiotic Resistance can be Caused by Small Amounts of Antibiotics: Study

by Colleen Fleiss on April 24, 2018 at 1:49 AM
Font : A-A+

Antibiotic Resistance can be Caused by Small Amounts of Antibiotics: Study

Bacteria exposed to low doses of antibiotics developed resistance to antibiotic levels that were more than a thousand times higher than the initial level to which the bacteria were subjected, found study from Uppsala University.

Antibiotic-resistant bacteria are a global and growing problem in health care. To be able to prevent further development of resistance developing, it is important to understand where and how antibiotic resistance in bacteria arises.

Advertisement


In the present study in question, published in Nature Communications, the researchers have investigated how prolonged exposure to low levels of antibiotics contributes to the development of bacterial antibiotic resistance. During a course of antibiotics, a high proportion of the antibiotic dose is excreted in the urine in unchanged, active form, and can then spread into watercourses, lakes and soil in the wastewater. Consequently, these environments may contain low levels of antibiotics. In some parts of the world, large quantities of antibiotics are used in meat production and aquaculture, where small doses of antibiotics are added to the animal feed to make the animals grow faster. This means that the bacteria in their intestines are exposed to low levels of antibiotics over long periods and these bacteria can then, in turn, infect people via food, for example.

In the paper, the researchers show that low concentrations of antibiotics, too, play a major part in the development of resistance. It was also found that the mutations in the bacterial DNA that cause resistance are of a different type than if they have been exposed to high doses. During the experiment, the bacteria eventually acquired several mutations. Each of these yielded low resistance, but together they brought about very high resistance. In addition, the mutations took place mainly in genes that have not previously been regarded as typical resistance genes, suggesting that the number of genes capable of promoting development of resistance has been greatly underestimated.

"The results are interesting because they show that the very low antibiotic concentrations present in many environments, too, can lead to a high degree of resistance and contribute to the problem of resistance," says Professor Dan I Andersson, who headed the study.

Source: Eurekalert
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
Advertisement
News Category
What's New on Medindia
International Day of Persons with Disabilities 2021 - Fighting for Rights in the Post-COVID Era
Effect of Blood Group Type on COVID-19 Risk and Severity
Woman with Rare Spinal Cord Defect from Birth Sues Doctor
View all

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
MRSA - The Super Bug Drug Resistance - Antibiotic Resistance Antibiotics Eye Infections Natural Antibiotics to Fight Bacterial Infections Vancomycin-Resistant Enterococci (VRE) Boils - Treatment by Drugs Multiple Drug Allergy Syndrome Interaction of Antibiotics with Dairy Products Antibiotic Resistance - An Emerging Global Crisis 

Recommended Reading
Drug Resistance - Antibiotic Resistance
Drug resistance is often a problem in malaria, tuberculosis, HIV, sexually transmitted diseases and ...
Antibiotics
Antibiotics are among the most used and abused medications. This article explains some general ......
Quiz on Antibiotics
Your doctor may suggest antibiotics at the first sight of an infection, but how much do you ......
Raman Spectroscopy Helps Find the Right Drug with Drug Resistance Test
Drug resistance by bacteria can be tested with Raman spectroscopy. This fast and simple test helps ....
Antibiotic Resistance - An Emerging Global Crisis
Antibiotic resistance refers to the adaption of bacteria that allows them to grow even in the presen...
Boils - Treatment by Drugs
Diabetes patients have reduced immunity, which makes them more susceptible to skin infections like b...
Eye Infections
Eye infection is a common problem that often causes pain and discomfort to the eyes. Common symptoms...
Interaction of Antibiotics with Dairy Products
Antibiotics like tetracyclines and fluoroquinolones used in the treatment of bacterial infections in...
MRSA - The Super Bug
MRSA infection is the most dreaded hospital or community acquired infection that can become ......
Multiple Drug Allergy Syndrome
Multiple drug allergy syndrome or multiple drug hypersensitivity syndrome is a condition that causes...
Natural Antibiotics to Fight Bacterial Infections
Fighting infections the natural way and preventing them is always more effective than consuming medi...
Vancomycin-Resistant Enterococci (VRE)
Enterococci are a group of gram-negative bacteria that mostly inhabit the human gut. At present ther...

Disclaimer - All information and content on this site are for information and educational purposes only. The information should not be used for either diagnosis or treatment or both for any health related problem or disease. Always seek the advice of a qualified physician for medical diagnosis and treatment. Full Disclaimer

© All Rights Reserved 1997 - 2021

This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use