German researchers have developed nanoparticles to deliver drug to the site of infection to increase treatment efficacy and overcoming resistance.

The researchers created nanoparticles from a biodegradable polymer oil, stabilizer, and the antibiotic clarithromycin. The package is about the size of a virus, allowing it to reach the target. The researchers tested these nanoparticles using Staphylococcus aureus as the target bacteria.
Using aerosol deposition, the researchers showed that the antibiotic successfully penetrated bacterial biofilms and reached the lung cells.
Dr Cristiane Carvalho-Wodarz, Helmholtz Institute for Pharmaceutical Research, said, “Using nanoparticles to deliver drugs to a local site of infection is a promising strategy for overcoming side effects, increasing treatment efficacy, and overcoming resistance.”
The nanoparticles are highly stable and do not provoke toxic effect, release the drug over a sustained period, and they can overcome cellular barriers, said Dr Cristiane.
Advertisement