New research from Lund University in Sweden says that a recently discovered HIV strain leads to significantly faster development of AIDS than currently prevalent forms.
The period from infection to development of AIDS was the shortest reported among HIV-1 types, at around five years. There are over 60 different epidemic strains of HIV-1 in the world, and geographic regions are often dominated by one or two of these. If a person becomes infected with two different strains, they can fuse and a recombined form can occur.
"Recombinants seem to be more vigorous and more aggressive than the strains from which they developed", explained Angelica Palm, a doctoral student at Lund University.The recombinant studied is called A3/02 and is a cross between the two most common strains in Guinea-Bissau, West Africa - 02AG and A3. It has previously been described by Joakim Esbjörnsson, a postdoctoral fellow at the University of Oxford, who is a co-author of the study.So far, the new strain has only been identified in West Africa, but other studies have shown that the global spread of different recombinants is increasing.
We therefore need to be aware of how the HIV-1 epidemic changes over time", said Patrik Medstrand, Professor of Clinical Virology at Lund University. The research is based on a unique long-term follow-up of HIV-infected individuals in Guinea-Bissau, a project run by Lund University. In future research, Angelica Palm and her colleagues hope to be able to continue researching the characteristics of recombinant viruses and the presence of these among HIV carriers in Europe.For health services, the new research results mean a need to be aware that certain HIV-1 types can be more aggressive than others, according to the research team.