About Careers Internship MedBlog Contact us
Medindia LOGIN REGISTER
Advertisement

A More Precise Analysis of How Cells React to Stress

by Julia Samuel on February 10, 2016 at 3:41 PM
Font : A-A+

A More Precise Analysis of How Cells React to Stress

Stress is caused either by environmental factors or the the body's reaction to inflammation, and can lead to cancer or cardiovascular diseases. When cells are exposed to stress, different repair and detoxification mechanisms are triggered to protect the cells from damage.

The cells react by chemically modifying different proteins, which change their activity and function. ADP-ribosylation is a central response in this stress reaction: enzymes place small molecules onto specific parts of a protein or remove them, thereby activating or deactivating the protein. This reaction turns on a cascade of processes that allow the cell to adapt to the stress and survive.

Advertisement


Maintaining health of the chromosomes, which carry the genetic information, is a vital aspect in this regard. Chromosomes are organized in such a way that the genetic information in the form of DNA is wrapped around proteins, the chromatin. It has been known for a long time that some of these proteins become ADP-ribosylated under certain stress conditions, which help the cell to deal with stress-induced damages. However, it has been so far unclear, where precisely on the chromatin this ADP-ribosylation occurs. Suitable methods to answer this question did not exist.

New method permits a better understanding of the cellular stress reaction

A group of researchers from the Department of Molecular Mechanisms of Disease (formerly Institute of Veterinary Biochemistry and Molecular Biology) of the University of Zurich have now established a new technique called "ADPr-ChAP" that allows the identification of the chromatin sites that become modified after a cell stress. "This new technique will now allow more closely investigating where and how ADP-ribosylation of the chromatin regulates its structure and chromatin-associated processes such as DNA replication, DNA repair or transcription," says Professor Michael O. Hottiger, who leads the study.
Advertisement

"The technique will now allow us to much more precisely identify which proteins become ADP-ribosylated on the genome-wide level and at specific loci. This will help us to better understand how a cell responds to a certain stress", Hottiger concludes. With this new method, the scientific community now has a reliable tool to identify the molecular signaling pathways that play a central role in cellular stress responses. Eventually, the researchers want to find new ways of interfering with disease-making processes in the body, such as those prevailing in chronic inflammation and cancer.



Source: Medindia
Advertisement

Advertisement
News A-Z
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
What's New on Medindia
Know More About Mitochondria
Top 10 Foods for Decreasing DHT Production and Preventing Hair Fall
Alarming Cesarean Section Trends in India - Convenience or Compulsion of Corporate Healthcare
View all
Recommended Reading
News Archive
Date
Category
News Category

Medindia Newsletters Subscribe to our Free Newsletters!
Terms & Conditions and Privacy Policy.

More News on:
Parkinsons Disease Surgical Treatment Amyotrophic Lateral Sclerosis (ALS) 

Most Popular on Medindia

Drug Side Effects Calculator Selfie Addiction Calculator Drug Interaction Checker Blood - Sugar Chart Pregnancy Confirmation Calculator The Essence of Yoga Iron Intake Calculator Drug - Food Interactions Vent Forte (Theophylline) Indian Medical Journals
This site uses cookies to deliver our services. By using our site, you acknowledge that you have read and understand our Cookie Policy, Privacy Policy, and our Terms of Use
open close
ASK A DOCTOR ONLINE

×

A More Precise Analysis of How Cells React to Stress Personalised Printable Document (PDF)

Please complete this form and we'll send you a personalised information that is requested

You may use this for your own reference or forward it to your friends.

Please use the information prudently. If you are not a medical doctor please remember to consult your healthcare provider as this information is not a substitute for professional advice.

Name *

Email Address *

Country *

Areas of Interests