Causes of Leucopenia

What are the Causes of leucopenia?

Leucopenia can be caused by various medical conditions and intake of certain drugs.

Leucopenia is caused by one of the following-

  • Infections, such as influenza, typhoid, malaria, tuberculosis or sepsis.
  • Diseases of the bone marrow.
  • Congenital disorders like Kostmann's syndrome which is characterized by diminished bone marrow function.
  • Cancer or other diseases that damage bone marrow.
  • Autoimmune disorders like HIV or SLE that destroys white blood cells or bone marrow cells.
  • Chemotherapy- Drugs like azathioprine (given in transplant patients) can cause leucopenia. Many of the drugs which are used to treat cancer may also cause leucopenia.
  • Hypersensitivity to several commonly used medications like antibiotics (minocycline) or diuretics.
  • Nutritional deficiencies- Vitamin B12, zinc, copper and folate deficiency can lead to leucopenia.
  • Enlargement of spleen (splenomegaly)
  • Aplastic anemia
  • Radiation